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Cooling of medial septum reveals theta phase lag coordination of hippocampal cell assemblies

View ORCID ProfilePeter Petersen, View ORCID ProfileGyörgy Buzsáki
doi: https://doi.org/10.1101/2019.12.19.883421
Peter Petersen
1Neuroscience Institute, New York University, New York, NY 10016, USA
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György Buzsáki
1Neuroscience Institute, New York University, New York, NY 10016, USA
2Department of Neurology Langone Medical Center, New, York University, New York, NY 10016, USA, Center for Neural Science, New York University, New York, NY 10003, USA
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  • For correspondence: gyorgy.buzsaki@nyumc.org
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Summary

Hippocampal theta oscillations coordinate neuronal firing to support memory and spatial navigation. The medial septum (MS) is critical in theta generation by two possible mechanisms: either a unitary ‘pacemaker’ timing signal is imposed on the hippocampal system or it may assist in organizing subcircuits within the phase space of theta oscillations. We used temperature manipulation of the MS to confront these models. Cooling of the MS reduced both theta frequency and power, was associated with enhanced incidence of errors in a spatial navigation task, but did not affect the spatial map. MS cooling decreased theta frequency oscillations of place cells, reduced distance-time compression but preserved distance-phase compression of place field sequences within the theta cycle. We suggest that reciprocal MS-hippocampal communication is essential for sustaining theta phase-coordination of cell assemblies and, in turn, supporting its role in spatial memory.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted December 20, 2019.
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Cooling of medial septum reveals theta phase lag coordination of hippocampal cell assemblies
Peter Petersen, György Buzsáki
bioRxiv 2019.12.19.883421; doi: https://doi.org/10.1101/2019.12.19.883421
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Cooling of medial septum reveals theta phase lag coordination of hippocampal cell assemblies
Peter Petersen, György Buzsáki
bioRxiv 2019.12.19.883421; doi: https://doi.org/10.1101/2019.12.19.883421

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