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Categorical signaling of the strongest stimulus by an inhibitory midbrain nucleus

View ORCID ProfileHannah M. Schryver, Malgorzata Straka, View ORCID ProfileShreesh P. Mysore
doi: https://doi.org/10.1101/2019.12.19.883702
Hannah M. Schryver
Department of Psychological and Brain Sciences, 3400 N. Charles St, Ames Hall 224, Johns Hopkins University
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Malgorzata Straka
Paradromics, Inc., 3400 N. Charles St, Ames Hall 224, Johns Hopkins University
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Shreesh P. Mysore
Department of Psychological and Brain Sciences, 3400 N. Charles St, Ames Hall 224, Johns Hopkins UniversityThe Solomon H. Snyder Department of Neuroscience, 3400 N. Charles St, Ames Hall 224, Johns Hopkins University
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  • For correspondence: shreesh.mysore@jhu.edu
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ABSTRACT

The isthmi pars magnocellularis (Imc), a group of inhibitory neurons in the vertebrate midbrain tegmentum, orchestrates stimulus competition and spatial selection in the optic tectum (OT). Here, we investigate the properties of relative-strength dependent competitive interactions within the barn owl Imc. Imc neurons exhibit switch-like as well as gradual response profiles as a function of relative stimulus strength, do so for competing stimuli both within and across sensory modalities, and signal the strongest stimulus in a dynamically flexible manner. Notably, Imc signals the strongest stimulus more categorically (with greater precision), and earlier than the OT. Paired recordings at spatially aligned Imc and OT sites reveal that although some properties of stimulus competition are correlated, others are set independently. Our results demonstrate that the Imc is itself an active site of competition, and may be the first site in the midbrain selection network at which stimulus competition is resolved.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted December 20, 2019.
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Categorical signaling of the strongest stimulus by an inhibitory midbrain nucleus
Hannah M. Schryver, Malgorzata Straka, Shreesh P. Mysore
bioRxiv 2019.12.19.883702; doi: https://doi.org/10.1101/2019.12.19.883702
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Categorical signaling of the strongest stimulus by an inhibitory midbrain nucleus
Hannah M. Schryver, Malgorzata Straka, Shreesh P. Mysore
bioRxiv 2019.12.19.883702; doi: https://doi.org/10.1101/2019.12.19.883702

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