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The role of the anterior intraparietal sulcus and the lateral occipital cortex in fingertip force scaling and weight perception during object lifting

View ORCID ProfileVonne van Polanen, Guy Rens, View ORCID ProfileMarco Davare
doi: https://doi.org/10.1101/2019.12.20.883918
Vonne van Polanen
1Movement Control and Neuroplasticity Research Group, Department of Movement Sciences, Biomedical Sciences group, KU Leuven, 3001 Leuven, Belgium
2Leuven Brain Institute, KU Leuven, 3001 Leuven, Belgium
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  • For correspondence: vonne.vanpolanen@kuleuven.be
Guy Rens
1Movement Control and Neuroplasticity Research Group, Department of Movement Sciences, Biomedical Sciences group, KU Leuven, 3001 Leuven, Belgium
2Leuven Brain Institute, KU Leuven, 3001 Leuven, Belgium
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Marco Davare
3Department of Clinical Sciences, College of Health and Life Sciences, Brunel University London, UB8 3PN Uxbridge, United Kingdom
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ABSTRACT

Skillful object lifting relies on scaling fingertip forces according to the object’s weight. When no visual cues about weight are available, force planning relies on recent lifting experience. Recently, we showed that previously lifted objects also affect weight estimation, as objects are perceived to be lighter when lifted after heavy objects compared to light ones. Here, we investigated the underlying neural mechanisms mediating these effects. We asked participants to lift objects and estimate their weight. Simultaneously, we applied transcranial magnetic stimulation (TMS) during the dynamic loading or static holding phase. Two subject groups received TMS of either the anterior intraparietal sulcus (aIPS) or lateral occipital area (LO), known to be important nodes in object grasping and perception. We hypothesized that TMS-induced disruption of aIPS and LO would alter force scaling and weight perception. Contrary to our hypothesis, we did not find effects of aIPS or LO stimulation on force planning or weight estimation caused by previous lifting experience. However, we found that TMS of both areas increased grip forces, but only when applied during dynamic loading, and decreased weight estimation, but only when applied during static holding, suggesting time-specific effects. Interestingly, our results also indicate that TMS over LO, but not aIPS, affected load force scaling specifically for heavy objects, which further indicates that planning of load and grip forces might be controlled differently. These findings provide new insights on the interactions between brain networks mediating action and perception during object manipulation.

NEW & NOTEWORTHY This article provides new insights into the neural mechanisms underlying object lifting and perception. Using transcranial magnetic stimulation during object lifting, we show that effects of previous experience on force scaling and weight perception are not mediated by the anterior intraparietal sulcus nor the lateral occipital cortex (LO). In contrast, we highlight a unique role for LO in load force scaling, suggesting different brain processes for grip and load force scaling in object manipulation.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license.
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Posted December 20, 2019.
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The role of the anterior intraparietal sulcus and the lateral occipital cortex in fingertip force scaling and weight perception during object lifting
Vonne van Polanen, Guy Rens, Marco Davare
bioRxiv 2019.12.20.883918; doi: https://doi.org/10.1101/2019.12.20.883918
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The role of the anterior intraparietal sulcus and the lateral occipital cortex in fingertip force scaling and weight perception during object lifting
Vonne van Polanen, Guy Rens, Marco Davare
bioRxiv 2019.12.20.883918; doi: https://doi.org/10.1101/2019.12.20.883918

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