Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

MGMM: An R Package for fitting Gaussian Mixture Models on Incomplete Data

View ORCID ProfileZachary R. McCaw, Hanna Julienne, View ORCID ProfileHugues Aschard
doi: https://doi.org/10.1101/2019.12.20.884551
Zachary R. McCaw
1Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Zachary R. McCaw
  • For correspondence: zrmacc@gmail.com
Hanna Julienne
2Groupe de Génétique Statistique, Département de Génomes and Génétique, Département Biologie Computation-nelle, Institut Pasteur, 75015 Paris, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hugues Aschard
2Groupe de Génétique Statistique, Département de Génomes and Génétique, Département Biologie Computation-nelle, Institut Pasteur, 75015 Paris, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Hugues Aschard
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Data/Code
  • Preview PDF
Loading

Abstract

Although missing data are prevalent in applications, existing implementations of Gaussian mixture models (GMMs) require complete data. Standard practice is to perform complete case analysis or imputation prior to model fitting. Both approaches have serious drawbacks, potentially resulting in biased and unstable parameter estimates. Here we present MGMM, an R package for fitting GMMs in the presence of missing data. Using three case studies on real and simulated data sets, we demonstrate that, when the underlying distribution is near-to a GMM, MGMM is more effective at recovering the true cluster assignments than state of the art imputation followed by standard GMM. Moreover, MGMM provides an accurate assessment of cluster assignment uncertainty even when the generative distribution is not a GMM. This assessment may be used to identify unassignable observations. MGMM is available as an R package on CRAN: https://CRAN.R-project.org/package=MGMM.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • Contact: Zachary R. McCaw: zmccaw{at}alumni.harvard.edu, Hanna Julienne: hanna.julienne{at}pasteur.fr.

  • The manuscript has been updated to include a full presentation of the statistical methods, detailed software usage examples, and an expanded benchmarking analysis.

  • https://archive.ics.uci.edu/ml/datasets/gene+expression+cancer+RNA-Seq

  • https://CRAN.R-project.org/package=MGMM

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Back to top
PreviousNext
Posted October 03, 2020.
Download PDF
Data/Code
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
MGMM: An R Package for fitting Gaussian Mixture Models on Incomplete Data
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
MGMM: An R Package for fitting Gaussian Mixture Models on Incomplete Data
Zachary R. McCaw, Hanna Julienne, Hugues Aschard
bioRxiv 2019.12.20.884551; doi: https://doi.org/10.1101/2019.12.20.884551
Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
Citation Tools
MGMM: An R Package for fitting Gaussian Mixture Models on Incomplete Data
Zachary R. McCaw, Hanna Julienne, Hugues Aschard
bioRxiv 2019.12.20.884551; doi: https://doi.org/10.1101/2019.12.20.884551

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Bioinformatics
Subject Areas
All Articles
  • Animal Behavior and Cognition (2235)
  • Biochemistry (4302)
  • Bioengineering (2958)
  • Bioinformatics (13483)
  • Biophysics (5959)
  • Cancer Biology (4633)
  • Cell Biology (6641)
  • Clinical Trials (138)
  • Developmental Biology (3939)
  • Ecology (6240)
  • Epidemiology (2053)
  • Evolutionary Biology (9181)
  • Genetics (6883)
  • Genomics (8803)
  • Immunology (3918)
  • Microbiology (11286)
  • Molecular Biology (4458)
  • Neuroscience (25625)
  • Paleontology (183)
  • Pathology (722)
  • Pharmacology and Toxicology (1209)
  • Physiology (1776)
  • Plant Biology (3999)
  • Scientific Communication and Education (892)
  • Synthetic Biology (1194)
  • Systems Biology (3627)
  • Zoology (654)