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Adenosine receptor and its downstream targets, mod(mdg4) and Hsp70, work as a signaling pathway modulating cytotoxic damage in Drosophila

View ORCID ProfileYu-Hsien Lin, Houda Ouns Maaroufi, Lucie Kucerova, Lenka Rouhova, Tomas Filip, Michal Zurovec
doi: https://doi.org/10.1101/2019.12.22.886143
Yu-Hsien Lin
1Biology Centre of the Czech Academy of Sciences, Institute of Entomology, Ceske Budejovice, Czech Republic
2Faculty of Science, University of South Bohemia, Ceske Budejovice, Czech Republic
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  • For correspondence: r99632012@gmail.com zurovec@entu.cas.cz
Houda Ouns Maaroufi
1Biology Centre of the Czech Academy of Sciences, Institute of Entomology, Ceske Budejovice, Czech Republic
2Faculty of Science, University of South Bohemia, Ceske Budejovice, Czech Republic
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Lucie Kucerova
1Biology Centre of the Czech Academy of Sciences, Institute of Entomology, Ceske Budejovice, Czech Republic
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Lenka Rouhova
1Biology Centre of the Czech Academy of Sciences, Institute of Entomology, Ceske Budejovice, Czech Republic
2Faculty of Science, University of South Bohemia, Ceske Budejovice, Czech Republic
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Tomas Filip
1Biology Centre of the Czech Academy of Sciences, Institute of Entomology, Ceske Budejovice, Czech Republic
2Faculty of Science, University of South Bohemia, Ceske Budejovice, Czech Republic
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Michal Zurovec
1Biology Centre of the Czech Academy of Sciences, Institute of Entomology, Ceske Budejovice, Czech Republic
2Faculty of Science, University of South Bohemia, Ceske Budejovice, Czech Republic
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  • For correspondence: r99632012@gmail.com zurovec@entu.cas.cz
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Summary

Adenosine (Ado) is an important signaling molecule involved in stress responses. Studies in mammalian models have shown that Ado regulates signaling mechanisms involved in ‘danger-sensing’ and tissue-protection. Yet, little is known about the role of Ado signaling in Drosophila. In the present study, we observed lower extracellular Ado concentration and suppressed expression of Ado transporters in flies expressing mutant huntingtin protein (mHTT). We altered Ado signaling using genetic tools and found that the overexpression of Ado metabolic enzymes, as well as the suppression of Ado receptor (AdoR) and transporters (ENTs), were able to minimize mHTT-induced mortality. We also identified the downstream targets of the AdoR pathway, the modifier of mdg4 (Mod(mdg4)) and heat-shock protein 70 (Hsp70), which carry out its function. Finally, we showed that a decrease in Ado signaling affect other Drosophila stress reactions, including paraquat and heat-shock treatments. Our study provides important insights into how Ado regulates stress responses in Drosophila.

Competing Interest Statement

The authors have declared no competing interest.

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Posted January 11, 2021.
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Adenosine receptor and its downstream targets, mod(mdg4) and Hsp70, work as a signaling pathway modulating cytotoxic damage in Drosophila
Yu-Hsien Lin, Houda Ouns Maaroufi, Lucie Kucerova, Lenka Rouhova, Tomas Filip, Michal Zurovec
bioRxiv 2019.12.22.886143; doi: https://doi.org/10.1101/2019.12.22.886143
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Adenosine receptor and its downstream targets, mod(mdg4) and Hsp70, work as a signaling pathway modulating cytotoxic damage in Drosophila
Yu-Hsien Lin, Houda Ouns Maaroufi, Lucie Kucerova, Lenka Rouhova, Tomas Filip, Michal Zurovec
bioRxiv 2019.12.22.886143; doi: https://doi.org/10.1101/2019.12.22.886143

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