Article Information
History
- December 26, 2019.
Copyright
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.
Author Information
- Thomas E. Wallach1,2,3,
- Vasudha Srivastava2,
- Efren Reyes2,3,
- Ophir D. Klein6,7 and
- Zev J. Gartner2,3,4,5,*
- 1Department of Pediatrics, Division of Pediatric Gastroenterology, University of California San Francisco, San Francisco, California, USA
- 2Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, USA
- 3Tetrad graduate program, University of California San Francisco, San Francisco, California, USA
- 4Center for Cellular Construction, University of California San Francisco, San Francisco, California, USA
- 5Chan-Zuckerberg Biohub, San Francisco, California, USA
- 6Program in Craniofacial Biology and Department of Orofacial Sciences, University of California San Francisco, San Francisco, California, USA
- 7Department of Pediatrics and Institute for Human Genetics, University of California San Francisco, San Francisco, California, USA
- ↵*CORRESPONDENCE: Zev J. Gartner, 600 16th St. Rm N512E, UCSF Box 2280, San Francisco, CA 94158, United States, Zev.gartner{at}ucsf.edu, 415-514-9962
AUTHOR CONTRIBUTIONS: T.E.W. and Z.J.G. conceptualized the study. T.E.W. designed experiments, carried out barrier function experiments in Caco2 and enteroid models, RNA sequencing analysis, drafted the manuscript, and figure design. V.S. designed experiments, performed RNAseq analysis, figure design, statistical analyses, and edited the manuscript. O.D.K. provided material support for enteroid culture and edited the manuscript. E.R. assisted in enteroid culture, experimental design, imaging, and co-wrote the manuscript. Z.J.G. designed experiments, supervised the research, and co-wrote and edited the manuscript.
Posted December 26, 2019.
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