Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Double dissociation of fMRI activity in the caudate nucleus supports de novo motor skill learning

Yera Choi, Emily Yunha Shin, Sungshin Kim
doi: https://doi.org/10.1101/2019.12.24.887786
Yera Choi
1Center for Neuroscience Imaging Research, Institute for Basic Science, Suwon 16419, Republic of Korea
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Emily Yunha Shin
1Center for Neuroscience Imaging Research, Institute for Basic Science, Suwon 16419, Republic of Korea
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sungshin Kim
1Center for Neuroscience Imaging Research, Institute for Basic Science, Suwon 16419, Republic of Korea
2Sungkyunkwan University, Suwon 16419, Republic of Korea
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: sungshin0207@gmail.com
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Supplementary material
  • Preview PDF
Loading

Abstract

Motor skill learning involves a complex process of generating novel movement patterns typically guided by evaluative feedback such as reward. Many studies have suggested that two separate circuits in the basal ganglia, rostral and caudal, are implicated in early goal-directed and later automatic stages of motor skill learning, respectively. However, there remains much to be elucidated about the respective involvement of the basal ganglia circuits in learning motor skills from scratch, which requires learning arbitrary action-outcome associations. To investigate this issue, we conducted a novel human fMRI experiment in which the participants learned to control a computer cursor on a screen by manipulating their right fingers. The experiment consisted of two fMRI sessions separated by five behavioral training sessions over multiple days. We discovered a double dissociation of fMRI activities in the rostral and caudal caudate nucleus, which were associated with skill performance in the early and late stages of learning. Moreover, we found that cognitive and sensorimotor cortico-caudate interactions distinctively predicted individual learning performance. In line with recent non-human primate studies, our results support the existence of parallel cortico-caudate networks involved in goal-directed and automatic stages of de novo motor skill learning.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Back to top
PreviousNext
Posted December 27, 2019.
Download PDF

Supplementary Material

Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Double dissociation of fMRI activity in the caudate nucleus supports de novo motor skill learning
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Double dissociation of fMRI activity in the caudate nucleus supports de novo motor skill learning
Yera Choi, Emily Yunha Shin, Sungshin Kim
bioRxiv 2019.12.24.887786; doi: https://doi.org/10.1101/2019.12.24.887786
Digg logo Reddit logo Twitter logo Facebook logo Google logo LinkedIn logo Mendeley logo
Citation Tools
Double dissociation of fMRI activity in the caudate nucleus supports de novo motor skill learning
Yera Choi, Emily Yunha Shin, Sungshin Kim
bioRxiv 2019.12.24.887786; doi: https://doi.org/10.1101/2019.12.24.887786

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Neuroscience
Subject Areas
All Articles
  • Animal Behavior and Cognition (3691)
  • Biochemistry (7800)
  • Bioengineering (5678)
  • Bioinformatics (21295)
  • Biophysics (10584)
  • Cancer Biology (8179)
  • Cell Biology (11948)
  • Clinical Trials (138)
  • Developmental Biology (6764)
  • Ecology (10401)
  • Epidemiology (2065)
  • Evolutionary Biology (13876)
  • Genetics (9709)
  • Genomics (13075)
  • Immunology (8151)
  • Microbiology (20022)
  • Molecular Biology (7859)
  • Neuroscience (43073)
  • Paleontology (321)
  • Pathology (1279)
  • Pharmacology and Toxicology (2261)
  • Physiology (3353)
  • Plant Biology (7232)
  • Scientific Communication and Education (1314)
  • Synthetic Biology (2008)
  • Systems Biology (5539)
  • Zoology (1128)