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IRAK1-mediated coincidence detection of microbial signals licenses inflammasome activation
Sharat J. Vayttaden, Margery Smelkinson, Orna Ernst, Rebecca J. Carlson, Jing Sun, Clinton Bradfield, Michael G. Dorrington, Jonathan Liang, Nicolas Bouladoux, Rachel A. Gottschalk, Kyu-Seon Oh, Gianluca Pegoraro, Sundar Ganesan, Dominic De Nardo, Eicke Latz, Yasmine Belkaid, Rajat R. Varma, Iain D.C. Fraser
doi: https://doi.org/10.1101/2019.12.26.888776
Sharat J. Vayttaden
1Signaling Systems Section, Laboratory of Immune System Biology, NIAID, Bethesda, MD, USA
Margery Smelkinson
2Research Technologies Branch, NIAID, Bethesda, MD, USA
Orna Ernst
1Signaling Systems Section, Laboratory of Immune System Biology, NIAID, Bethesda, MD, USA
Rebecca J. Carlson
1Signaling Systems Section, Laboratory of Immune System Biology, NIAID, Bethesda, MD, USA
3Broad Institute of MIT and Harvard, Cambridge, MA, USA
4Department of Health Sciences and Technology, MIT, Cambridge, MA, USA
Jing Sun
1Signaling Systems Section, Laboratory of Immune System Biology, NIAID, Bethesda, MD, USA
Clinton Bradfield
1Signaling Systems Section, Laboratory of Immune System Biology, NIAID, Bethesda, MD, USA
Michael G. Dorrington
1Signaling Systems Section, Laboratory of Immune System Biology, NIAID, Bethesda, MD, USA
Jonathan Liang
1Signaling Systems Section, Laboratory of Immune System Biology, NIAID, Bethesda, MD, USA
Nicolas Bouladoux
5Metaorganism Immunity Section, Laboratory of Immune System Biology, NIAID, Bethesda, MD, USA
Rachel A. Gottschalk
6Lymphocyte Biology Section, Laboratory of Systems Biology, NIAID, Bethesda, MD, USA
7Department of Immunology, University of Pittsburgh, PA, USA
Kyu-Seon Oh
1Signaling Systems Section, Laboratory of Immune System Biology, NIAID, Bethesda, MD, USA
8Gene Regulation Section, NIA, Baltimore, MD, USA
Gianluca Pegoraro
9High-Throughput Imaging Facility, Center for Cancer Research, NCI, Bethesda, MD, USA
Sundar Ganesan
2Research Technologies Branch, NIAID, Bethesda, MD, USA
Dominic De Nardo
10Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Australia
11Institute of Innate Immunity, University Hospital, University of Bonn, Bonn, Germany
Eicke Latz
11Institute of Innate Immunity, University Hospital, University of Bonn, Bonn, Germany
Yasmine Belkaid
5Metaorganism Immunity Section, Laboratory of Immune System Biology, NIAID, Bethesda, MD, USA
Rajat R. Varma
12T-Cell Biophysics Unit, Laboratory of Systems Biology, NIAID, Bethesda, MD, USA
13Kleo Pharmaceuticals Inc., New Haven, CT, USA
Iain D.C. Fraser
1Signaling Systems Section, Laboratory of Immune System Biology, NIAID, Bethesda, MD, USA
Posted December 26, 2019.
IRAK1-mediated coincidence detection of microbial signals licenses inflammasome activation
Sharat J. Vayttaden, Margery Smelkinson, Orna Ernst, Rebecca J. Carlson, Jing Sun, Clinton Bradfield, Michael G. Dorrington, Jonathan Liang, Nicolas Bouladoux, Rachel A. Gottschalk, Kyu-Seon Oh, Gianluca Pegoraro, Sundar Ganesan, Dominic De Nardo, Eicke Latz, Yasmine Belkaid, Rajat R. Varma, Iain D.C. Fraser
bioRxiv 2019.12.26.888776; doi: https://doi.org/10.1101/2019.12.26.888776
IRAK1-mediated coincidence detection of microbial signals licenses inflammasome activation
Sharat J. Vayttaden, Margery Smelkinson, Orna Ernst, Rebecca J. Carlson, Jing Sun, Clinton Bradfield, Michael G. Dorrington, Jonathan Liang, Nicolas Bouladoux, Rachel A. Gottschalk, Kyu-Seon Oh, Gianluca Pegoraro, Sundar Ganesan, Dominic De Nardo, Eicke Latz, Yasmine Belkaid, Rajat R. Varma, Iain D.C. Fraser
bioRxiv 2019.12.26.888776; doi: https://doi.org/10.1101/2019.12.26.888776
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