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Crowdsourced mapping of unexplored target space of kinase inhibitors

View ORCID ProfileAnna Cichonska, View ORCID ProfileBalaguru Ravikumar, View ORCID ProfileRobert J Allaway, Sungjoon Park, Fangping Wan, View ORCID ProfileOlexandr Isayev, Shuya Li, View ORCID ProfileMichael Mason, Andrew Lamb, View ORCID ProfileZia-ur-Rehman Tanoli, View ORCID ProfileMinji Jeon, View ORCID ProfileSunkyu Kim, Mariya Popova, View ORCID ProfileStephen Capuzzi, Jianyang Zeng, Kristen Dang, Gregory Koytiger, View ORCID ProfileJaewoo Kang, View ORCID ProfileCarrow I. Wells, View ORCID ProfileTimothy M. Willson, The IDG-DREAM Drug-Kinase Binding Prediction Challenge Consortium, View ORCID ProfileTudor I. Oprea, View ORCID ProfileAvner Schlessinger, David H. Drewry, View ORCID ProfileGustavo Stolovitzky, View ORCID ProfileKrister Wennerberg, View ORCID ProfileJustin Guinney, View ORCID ProfileTero Aittokallio
doi: https://doi.org/10.1101/2019.12.31.891812
Anna Cichonska
Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, FinlandDepartment of Computer Science, Helsinki Institute for Information Technology (HIIT), Aalto University, Espoo, FinlandDepartment of Future Technologies, University of Turku, Turku, Finland
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  • ORCID record for Anna Cichonska
Balaguru Ravikumar
Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland
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Robert J Allaway
Computational Oncology, Sage Bionetworks, Seattle, WA, USA
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Sungjoon Park
Department of Computer Science and Engineering, Korea University, Seoul, Republic of Korea
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Fangping Wan
Institute for Interdisciplinary Information Sciences, Tsinghua University, Beijing, China, 100084
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Olexandr Isayev
Department of Chemistry, Carnegie Mellon University, Pittsburgh, PA
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Shuya Li
Institute for Interdisciplinary Information Sciences, Tsinghua University, Beijing, China, 100084
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Michael Mason
Computational Oncology, Sage Bionetworks, Seattle, WA, USA
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Andrew Lamb
Computational Oncology, Sage Bionetworks, Seattle, WA, USA
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Zia-ur-Rehman Tanoli
Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland
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  • ORCID record for Zia-ur-Rehman Tanoli
Minji Jeon
Department of Computer Science and Engineering, Korea University, Seoul, Republic of Korea
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Sunkyu Kim
Department of Computer Science and Engineering, Korea University, Seoul, Republic of Korea
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Mariya Popova
Department of Chemistry, Carnegie Mellon University, Pittsburgh, PA
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Stephen Capuzzi
Laboratory for Molecular Modeling, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599, United States
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Jianyang Zeng
Institute for Interdisciplinary Information Sciences, Tsinghua University, Beijing, China, 100084
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Kristen Dang
Computational Oncology, Sage Bionetworks, Seattle, WA, USA
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Gregory Koytiger
Immuneering Corporation, Cambridge, MA, USA
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Jaewoo Kang
Department of Computer Science and Engineering, Korea University, Seoul, Republic of Korea
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Carrow I. Wells
Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
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Timothy M. Willson
Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
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Tudor I. Oprea
Translational Informatics Division, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA
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Avner Schlessinger
Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA
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David H. Drewry
Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
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Gustavo Stolovitzky
IBM T J Watson Research Center, IBM, Yorktown Heights, NY, USA
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  • ORCID record for Gustavo Stolovitzky
Krister Wennerberg
Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark
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Justin Guinney
Computational Oncology, Sage Bionetworks, Seattle, WA, USA
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Tero Aittokallio
Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, FinlandDepartment of Computer Science, Helsinki Institute for Information Technology (HIIT), Aalto University, Espoo, FinlandDepartment of Mathematics and Statistics, University of Turku, Turku, FinlandInstitute for Cancer Research, Oslo University Hospital, Oslo, NorwayOslo Centre for Biostatistics and Epidemiology (OCBE), University of Oslo, Oslo, Norway
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  • For correspondence: tero.aittokallio@helsinki.fi
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Posted January 08, 2020.
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Crowdsourced mapping of unexplored target space of kinase inhibitors
Anna Cichonska, Balaguru Ravikumar, Robert J Allaway, Sungjoon Park, Fangping Wan, Olexandr Isayev, Shuya Li, Michael Mason, Andrew Lamb, Zia-ur-Rehman Tanoli, Minji Jeon, Sunkyu Kim, Mariya Popova, Stephen Capuzzi, Jianyang Zeng, Kristen Dang, Gregory Koytiger, Jaewoo Kang, Carrow I. Wells, Timothy M. Willson, The IDG-DREAM Drug-Kinase Binding Prediction Challenge Consortium, Tudor I. Oprea, Avner Schlessinger, David H. Drewry, Gustavo Stolovitzky, Krister Wennerberg, Justin Guinney, Tero Aittokallio
bioRxiv 2019.12.31.891812; doi: https://doi.org/10.1101/2019.12.31.891812
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Crowdsourced mapping of unexplored target space of kinase inhibitors
Anna Cichonska, Balaguru Ravikumar, Robert J Allaway, Sungjoon Park, Fangping Wan, Olexandr Isayev, Shuya Li, Michael Mason, Andrew Lamb, Zia-ur-Rehman Tanoli, Minji Jeon, Sunkyu Kim, Mariya Popova, Stephen Capuzzi, Jianyang Zeng, Kristen Dang, Gregory Koytiger, Jaewoo Kang, Carrow I. Wells, Timothy M. Willson, The IDG-DREAM Drug-Kinase Binding Prediction Challenge Consortium, Tudor I. Oprea, Avner Schlessinger, David H. Drewry, Gustavo Stolovitzky, Krister Wennerberg, Justin Guinney, Tero Aittokallio
bioRxiv 2019.12.31.891812; doi: https://doi.org/10.1101/2019.12.31.891812

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