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Spinal stretch reflexes support efficient control of reaching

View ORCID ProfileJeffrey Weiler, View ORCID ProfilePaul L Gribble, View ORCID ProfileJ. Andrew Pruszynski
doi: https://doi.org/10.1101/2020.01.06.896225
Jeffrey Weiler
Brain and Mind Institute, Western University, London, Ontario, CanadaDepartment of Physiology and Pharmacology, Western University, London, Ontario, CanadaDepartment of Psychology, Western University, London, Ontario, Canada
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Paul L Gribble
Brain and Mind Institute, Western University, London, Ontario, CanadaDepartment of Physiology and Pharmacology, Western University, London, Ontario, CanadaDepartment of Psychology, Western University, London, Ontario, Canada
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J. Andrew Pruszynski
Brain and Mind Institute, Western University, London, Ontario, CanadaDepartment of Physiology and Pharmacology, Western University, London, Ontario, CanadaDepartment of Psychology, Western University, London, Ontario, CanadaRobarts Research Institute, Western University, London, Ontario, Canada
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  • For correspondence: andrew.pruszynski@uwo.ca
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Abstract

Efficiently controlling the movement of our hand requires coordinating the motion of multiple joints of the arm. Although it is widely assumed that this type of efficient control is implemented by processing that occurs in the cerebral cortex and brain stem, recent work has shown that spinal circuits can generate efficient motor output that supports keeping the hand in a static location. Here, we show that a spinal pathway can also efficiently control the hand during reaching. In our first experiment we applied multi-joint mechanical perturbations to participant’s elbow and wrist as they began reaching towards a target. We found that spinal stretch reflexes evoked in elbow muscles were not proportional to how much the elbow muscles were stretched but instead were efficiently scaled to the hand’s distance from the target. In our second experiment we applied the same elbow and wrist perturbations but had participants change how they grasped the manipulandum, diametrically altering how the same wrist perturbation moved the hand relative to the reach target. We found that changing the arm’s orientation diametrically altered how spinal reflexes in the elbow muscles were evoked, and in such a way that were again efficiently scaled to the hand’s distance from the target. These findings demonstrate that spinal circuits can help efficiently control the hand during dynamic reaching actions, and show that efficient and flexible motor control is not exclusively dependent on processing that occurs within supraspinal regions of the nervous system.

Footnotes

  • Grants: This work was supported by a grant from the National Science and Engineering Research Council of Canada (NSERC Discovery Grant to J.A.P.: RGPIN-2015-06714). J.W. received a postdoctoral fellowship from NSERC and BrainsCAN. J.A.P. received a salary award from the Canada Research Chairs program.

  • Disclosures: The authors declare no conflict of interest

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted January 07, 2020.
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Spinal stretch reflexes support efficient control of reaching
Jeffrey Weiler, Paul L Gribble, J. Andrew Pruszynski
bioRxiv 2020.01.06.896225; doi: https://doi.org/10.1101/2020.01.06.896225
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Spinal stretch reflexes support efficient control of reaching
Jeffrey Weiler, Paul L Gribble, J. Andrew Pruszynski
bioRxiv 2020.01.06.896225; doi: https://doi.org/10.1101/2020.01.06.896225

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