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Population sequencing data reveal a compendium of mutational processes in human germline
Vladimir B. Seplyarskiy, Ruslan A. Soldatov, Ryan J. McGinty, Jakob M. Goldmann, Ryan Hernandez, Kathleen Barnes, Adolfo Correa, Esteban G. Burchard, Patrick T. Ellinor, Stephen T. McGarvey, Braxton D. Mitchell, Vasan S. Ramachandran, Susan Redline, Edwin Silverman, Scott T. Weiss, Donna K. Arnett, John Blangero, Eric Boerwinkle, Jiang He, Courtney Montgomery, D.C. Rao, Jerome I. Rotter, Jennifer A Brody, Yii-Der Ida Chen, Lisa de las Fuentes, Chii-Min Hwu, Stephen S. Rich, Ani W. Manichaikul, Josyf C. Mychaleckyj, Nicholette D. Palmer, Jennifer A. Smith, Sharon L.R. Kardia, Patricia A. Peyser, Lawrence F. Bielak, Timothy D. O’Connor, Leslie S. Emery, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, TOPMed Population Genetics Working Group, Christian Gilissen, Wendy S.W. Wong, Peter V. Kharchenko, Shamil Sunyaev
doi: https://doi.org/10.1101/2020.01.10.893024
Vladimir B. Seplyarskiy
1Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
2Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA
Ruslan A. Soldatov
2Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA
Ryan J. McGinty
1Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
2Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA
Jakob M. Goldmann
3Department of Human Genetics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands
Ryan Hernandez
4Quantitative Life Sciences, McGill University, Montreal, QC
Kathleen Barnes
5Department of Medicine, University of Colorado Denver, Aurora, CO 80045, USA
Adolfo Correa
6Department of Medicine, University of Mississippi Medical Center, Jackson, MS
7Department of Pediatrics, University of Mississippi Medical Center, Jackson, MS
8Department of Population Health Science, University of Mississippi Medical Center, Jackson, MS
Esteban G. Burchard
9Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA
10Department of Medicine, University of California, San Francisco, CA
Patrick T. Ellinor
11Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA
Stephen T. McGarvey
12International Health Institute, Brown University, Providence, RI
13Department of Epidemiology, Brown University, Providence, RI
14Department of Anthropology, Brown University, Providence, RI
Braxton D. Mitchell
15Department of Medicine, University of Maryland School of Medicine, Baltimore, MD
16Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD
17Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD
Vasan S. Ramachandran
18Department of Medicine, Boston University School of Medicine, Boston, MA
19Framingham Heart Study, Framingham, MA
Susan Redline
20Department of Medicine, Harvard Medical School, Boston, MA
21Department of Medicine, Brigham and Women’s Hospital, Boston, MA
Edwin Silverman
22Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA
Scott T. Weiss
20Department of Medicine, Harvard Medical School, Boston, MA
21Department of Medicine, Brigham and Women’s Hospital, Boston, MA
22Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA
Donna K. Arnett
23Department of Epidemiology, University of Kentucky, Lexington, KY
John Blangero
24Department of Human Genetics, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX
25South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX
Eric Boerwinkle
26University of Texas Health Science Center at Houston, Houston, TX
27Baylor College of Medicine Human Genome Sequencing Center, Houston, TX
Jiang He
28Department of Epidemiology, Tulane University, New Orleans, LA
29Tulane University Translational Science Institute, Tulane University, New Orleans, LA
Courtney Montgomery
30Division of Genomics and Data Science, Department of Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK
D.C. Rao
31Division of Biostatistics, Washington University in St. Louis, St. Louis, MO
Jerome I. Rotter
32Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA
33Department of Medicine, The Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA
Jennifer A Brody
34Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA, 98115
Yii-Der Ida Chen
35Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA
Lisa de las Fuentes
36Washington University, St. Louis, MO 63130
Chii-Min Hwu
37National Yang-Ming University School of Medicine, Taipei, Taiwan
Stephen S. Rich
38Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA
Ani W. Manichaikul
39University of Virginia Center for Public Health Genomics, Charlottesville, Virginia, USA
Josyf C. Mychaleckyj
39University of Virginia Center for Public Health Genomics, Charlottesville, Virginia, USA
Nicholette D. Palmer
40Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC
Jennifer A. Smith
41Department of Epidemiology, School of Public Health, University of Michigan, 1415 Washington Heights, Ann Arbor, MI 48109-2029
42Survey Research Center, Institute for Social Research, University of Michigan 426 Thompson St, Room Ann Arbor, MI 48104
Sharon L.R. Kardia
41Department of Epidemiology, School of Public Health, University of Michigan, 1415 Washington Heights, Ann Arbor, MI 48109-2029
Patricia A. Peyser
41Department of Epidemiology, School of Public Health, University of Michigan, 1415 Washington Heights, Ann Arbor, MI 48109-2029
Lawrence F. Bielak
41Department of Epidemiology, School of Public Health, University of Michigan, 1415 Washington Heights, Ann Arbor, MI 48109-2029
Timothy D. O’Connor
42Survey Research Center, Institute for Social Research, University of Michigan 426 Thompson St, Room Ann Arbor, MI 48104
43Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD
44Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD
Leslie S. Emery
45University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD
Christian Gilissen
3Department of Human Genetics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands
Wendy S.W. Wong
47Inova Translational Medicine Institute (ITMI), Inova Health Systems, Falls Church, VA, USA
Peter V. Kharchenko
2Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA
Shamil Sunyaev
1Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
2Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA
Article usage
Posted January 11, 2020.
Population sequencing data reveal a compendium of mutational processes in human germline
Vladimir B. Seplyarskiy, Ruslan A. Soldatov, Ryan J. McGinty, Jakob M. Goldmann, Ryan Hernandez, Kathleen Barnes, Adolfo Correa, Esteban G. Burchard, Patrick T. Ellinor, Stephen T. McGarvey, Braxton D. Mitchell, Vasan S. Ramachandran, Susan Redline, Edwin Silverman, Scott T. Weiss, Donna K. Arnett, John Blangero, Eric Boerwinkle, Jiang He, Courtney Montgomery, D.C. Rao, Jerome I. Rotter, Jennifer A Brody, Yii-Der Ida Chen, Lisa de las Fuentes, Chii-Min Hwu, Stephen S. Rich, Ani W. Manichaikul, Josyf C. Mychaleckyj, Nicholette D. Palmer, Jennifer A. Smith, Sharon L.R. Kardia, Patricia A. Peyser, Lawrence F. Bielak, Timothy D. O’Connor, Leslie S. Emery, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, TOPMed Population Genetics Working Group, Christian Gilissen, Wendy S.W. Wong, Peter V. Kharchenko, Shamil Sunyaev
bioRxiv 2020.01.10.893024; doi: https://doi.org/10.1101/2020.01.10.893024
Population sequencing data reveal a compendium of mutational processes in human germline
Vladimir B. Seplyarskiy, Ruslan A. Soldatov, Ryan J. McGinty, Jakob M. Goldmann, Ryan Hernandez, Kathleen Barnes, Adolfo Correa, Esteban G. Burchard, Patrick T. Ellinor, Stephen T. McGarvey, Braxton D. Mitchell, Vasan S. Ramachandran, Susan Redline, Edwin Silverman, Scott T. Weiss, Donna K. Arnett, John Blangero, Eric Boerwinkle, Jiang He, Courtney Montgomery, D.C. Rao, Jerome I. Rotter, Jennifer A Brody, Yii-Der Ida Chen, Lisa de las Fuentes, Chii-Min Hwu, Stephen S. Rich, Ani W. Manichaikul, Josyf C. Mychaleckyj, Nicholette D. Palmer, Jennifer A. Smith, Sharon L.R. Kardia, Patricia A. Peyser, Lawrence F. Bielak, Timothy D. O’Connor, Leslie S. Emery, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, TOPMed Population Genetics Working Group, Christian Gilissen, Wendy S.W. Wong, Peter V. Kharchenko, Shamil Sunyaev
bioRxiv 2020.01.10.893024; doi: https://doi.org/10.1101/2020.01.10.893024
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