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Reward-driven enhancements in motor control are robust to TMS manipulation

View ORCID ProfileOlivier Codol, View ORCID ProfileJoseph M. Galea, Roya Jalali, View ORCID ProfilePeter J. Holland
doi: https://doi.org/10.1101/2020.01.12.903419
Olivier Codol
1School of Psychology, University of Birmingham, UK
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  • For correspondence: codol.olivier@gmail.com
Joseph M. Galea
1School of Psychology, University of Birmingham, UK
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Roya Jalali
1School of Psychology, University of Birmingham, UK
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Peter J. Holland
1School of Psychology, University of Birmingham, UK
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Abstract

A wealth of evidence describes the strong positive impact that reward has on motor control at the behavioural level. However, surprisingly little is known regarding the neural mechanisms which underpin these effects, beyond a reliance on the dopaminergic system. In recent work, we developed a task that enabled the dissociation of the selection and execution components of an upper limb reaching movement. Our results demonstrated that both selection and execution are concommitently enhanced by immediate reward availability. Here, we investigate what the neural underpinnings of each component may be. To this end, we disrupted activity of the ventromedial prefrontal cortex and supplementary motor area using continuous theta-burst transcranial magnetic stimulation (cTBS) in a within-participant design (N=23). Both cortical areas are involved in reward processing and motor control, and we hypothesised that disruption of their activity would result in disruption of the reward-driven effects on action selection and execution, respectively. To increase statistical power, participants were pre-selected based on their sensitivity to reward in the reaching task. While reward did lead to enhanced perforance during the cTBS sessions and a control sham session, cTBS was ineffective in altering these effects. These results may provide evidence that other areas, such as the primary motor cortex or the premotor area, may drive the reward-based enhancements of motor performance.

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  • https://osf.io/tnkrj/

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted January 14, 2020.
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Reward-driven enhancements in motor control are robust to TMS manipulation
Olivier Codol, Joseph M. Galea, Roya Jalali, Peter J. Holland
bioRxiv 2020.01.12.903419; doi: https://doi.org/10.1101/2020.01.12.903419
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Reward-driven enhancements in motor control are robust to TMS manipulation
Olivier Codol, Joseph M. Galea, Roya Jalali, Peter J. Holland
bioRxiv 2020.01.12.903419; doi: https://doi.org/10.1101/2020.01.12.903419

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