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Sensory and Behavioral Components of Neocortical Signal Flow in Discrimination Tasks with Short-term Memory

Yasir Gallero-Salas, Balazs Laurenczy, Fabian F. Voigt, Ariel Gilad, View ORCID ProfileFritjof Helmchen
doi: https://doi.org/10.1101/2020.01.13.904284
Yasir Gallero-Salas
1Brain Research Institute, University of Zurich, Zurich, Switzerland
2Neuroscience Center Zurich, Zurich, Switzerland
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Balazs Laurenczy
1Brain Research Institute, University of Zurich, Zurich, Switzerland
2Neuroscience Center Zurich, Zurich, Switzerland
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Fabian F. Voigt
1Brain Research Institute, University of Zurich, Zurich, Switzerland
2Neuroscience Center Zurich, Zurich, Switzerland
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Ariel Gilad
1Brain Research Institute, University of Zurich, Zurich, Switzerland
3Hebrew University Medical School, Department of Medical Neurobiology, Institute of Medical Research Israel-Canada, Jerusalem 9112102, Israel
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  • For correspondence: Ariel.Gilad@mail.huji.ac.il helmchen@hifo.uzh.ch
Fritjof Helmchen
1Brain Research Institute, University of Zurich, Zurich, Switzerland
2Neuroscience Center Zurich, Zurich, Switzerland
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  • ORCID record for Fritjof Helmchen
  • For correspondence: Ariel.Gilad@mail.huji.ac.il helmchen@hifo.uzh.ch
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Abstract

In neocortex, each sensory modality engages distinct primary and secondary areas that route information further to association areas. Where signal flow may converge for maintaining information in short-term memory and how behavior may influence signal routing remain open questions. Using wide-field calcium imaging, we compared cortex-wide neuronal activity in layer 2/3 for mice trained in auditory and whisker-based tactile discrimination tasks with delayed response. In both tasks, mice were either active or passive during stimulus presentation, engaging in body movements or sitting quietly. Irrespective of behavioral strategy, auditory and tactile stimulation activated spatially segregated subdivisions of posterior parietal cortex (areas A and RL, respectively). In the subsequent delay period, in contrast, behavioral strategy rather than sensory modality determined where short-term memory was located: frontomedially in active trials and posterolaterally in passive trials. Our results suggest behavior-dependent routing of sensory-driven cortical information flow from modality-specific PPC subdivisions to higher association areas.

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Posted January 14, 2020.
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Sensory and Behavioral Components of Neocortical Signal Flow in Discrimination Tasks with Short-term Memory
Yasir Gallero-Salas, Balazs Laurenczy, Fabian F. Voigt, Ariel Gilad, Fritjof Helmchen
bioRxiv 2020.01.13.904284; doi: https://doi.org/10.1101/2020.01.13.904284
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Sensory and Behavioral Components of Neocortical Signal Flow in Discrimination Tasks with Short-term Memory
Yasir Gallero-Salas, Balazs Laurenczy, Fabian F. Voigt, Ariel Gilad, Fritjof Helmchen
bioRxiv 2020.01.13.904284; doi: https://doi.org/10.1101/2020.01.13.904284

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