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Differential functional connectivity underlying asymmetric reward-related activity in human and non-human primates

View ORCID ProfileAlizée Lopez-Persem, View ORCID ProfileLéa Roumazeilles, View ORCID ProfileDavide Folloni, Kévin Marche, View ORCID ProfileElsa F. Fouragnan, View ORCID ProfileNima Khalighinejad, View ORCID ProfileMatthew F. S. Rushworth, View ORCID ProfileJérôme Sallet
doi: https://doi.org/10.1101/2020.01.13.904565
Alizée Lopez-Persem
Wellcome Integrative Neuroimaging Centre, Department of Experimental Psychology, University of Oxford, Oxford, UKFRONTLAB, Institut du Cerveau et la Moelle épiniere (ICM), Sorbonne Université, INSERM, CNRS, HôpitalPitié Salpêtrière, Paris, France
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  • For correspondence: lopez.alizee@gmail.com jerome.sallet@psy.ox.ac.uk
Léa Roumazeilles
Wellcome Integrative Neuroimaging Centre, Department of Experimental Psychology, University of Oxford, Oxford, UK
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  • ORCID record for Léa Roumazeilles
Davide Folloni
Wellcome Integrative Neuroimaging Centre, Department of Experimental Psychology, University of Oxford, Oxford, UK
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Kévin Marche
Wellcome Integrative Neuroimaging Centre, Department of Experimental Psychology, University of Oxford, Oxford, UK
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Elsa F. Fouragnan
School of Psychology, University of Plymouth, Plymouth, UK
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Nima Khalighinejad
Wellcome Integrative Neuroimaging Centre, Department of Experimental Psychology, University of Oxford, Oxford, UK
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Matthew F. S. Rushworth
Wellcome Integrative Neuroimaging Centre, Department of Experimental Psychology, University of Oxford, Oxford, UK
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Jérôme Sallet
Wellcome Integrative Neuroimaging Centre, Department of Experimental Psychology, University of Oxford, Oxford, UKUniv Lyon, Université Lyon 1, Inserm, Stem Cell and Brain Research Institute U1208, Bron, France
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  • For correspondence: lopez.alizee@gmail.com jerome.sallet@psy.ox.ac.uk
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Abstract

The orbitofrontal cortex (OFC) is a key brain region involved in complex cognitive functions such as reward processing and decision-making. Neuroimaging studies have shown unilateral OFC response to reward-related variables, however, those studies rarely discussed the lateralization of this effect. Yet, some lesion studies suggest that the left and right OFC contribute differently to cognitive processes. We hypothesized that the OFC asymmetrical response to reward could reflect underlying hemispherical difference in OFC functional connectivity. Using restingstate and reward-related MRI data from humans and from rhesus macaques, we first identified a specific asymmetrical response of the lateral OFC to reward in both species. Crucially, the subregion showing the highest reward-related asymmetry (RRA) overlapped with the region showing the highest functional connectivity asymmetry (FCA). Furthermore, the two types of functional asymmetries were found to be significantly correlated across humans. Altogether, our results suggest a similar pattern of functional specialization between the left and right OFC is present in two primate species.

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Posted January 14, 2020.
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Differential functional connectivity underlying asymmetric reward-related activity in human and non-human primates
Alizée Lopez-Persem, Léa Roumazeilles, Davide Folloni, Kévin Marche, Elsa F. Fouragnan, Nima Khalighinejad, Matthew F. S. Rushworth, Jérôme Sallet
bioRxiv 2020.01.13.904565; doi: https://doi.org/10.1101/2020.01.13.904565
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Differential functional connectivity underlying asymmetric reward-related activity in human and non-human primates
Alizée Lopez-Persem, Léa Roumazeilles, Davide Folloni, Kévin Marche, Elsa F. Fouragnan, Nima Khalighinejad, Matthew F. S. Rushworth, Jérôme Sallet
bioRxiv 2020.01.13.904565; doi: https://doi.org/10.1101/2020.01.13.904565

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