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Drug mechanism-of-action discovery through the integration of pharmacological and CRISPR screens
Emanuel Gonçalves, Aldo Segura-Cabrera, Clare Pacini, Gabriele Picco, Fiona M. Behan, Patricia Jaaks, Elizabeth A. Coker, Donny van der Meer, Andrew Barthorpe, Howard Lightfoot, GDSC Screening Team, Andrew R. Leach, James T. Lynch, Ben Sidders, Claire Crafter, Francesco Iorio, Stephen Fawell, Mathew J. Garnett
doi: https://doi.org/10.1101/2020.01.14.905729
Emanuel Gonçalves
1Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK
Aldo Segura-Cabrera
2European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK
Clare Pacini
1Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK
Gabriele Picco
1Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK
Fiona M. Behan
1Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK
Patricia Jaaks
1Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK
Elizabeth A. Coker
1Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK
Donny van der Meer
1Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK
Andrew Barthorpe
1Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK
Howard Lightfoot
1Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK
1Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK
Andrew R. Leach
2European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK
James T. Lynch
3Research and Early Development, Oncology R&D, AstraZeneca, Cambridge, UK
Ben Sidders
3Research and Early Development, Oncology R&D, AstraZeneca, Cambridge, UK
Claire Crafter
3Research and Early Development, Oncology R&D, AstraZeneca, Cambridge, UK
Francesco Iorio
1Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK
5Human Technopole, Via Cristina Belgioioso, 20157 Milano, Italy
Stephen Fawell
4Research and Early Development, Oncology R&D, AstraZeneca, Waltham, MA 02451, USA
Mathew J. Garnett
1Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK
Article usage
Posted January 14, 2020.
Drug mechanism-of-action discovery through the integration of pharmacological and CRISPR screens
Emanuel Gonçalves, Aldo Segura-Cabrera, Clare Pacini, Gabriele Picco, Fiona M. Behan, Patricia Jaaks, Elizabeth A. Coker, Donny van der Meer, Andrew Barthorpe, Howard Lightfoot, GDSC Screening Team, Andrew R. Leach, James T. Lynch, Ben Sidders, Claire Crafter, Francesco Iorio, Stephen Fawell, Mathew J. Garnett
bioRxiv 2020.01.14.905729; doi: https://doi.org/10.1101/2020.01.14.905729
Drug mechanism-of-action discovery through the integration of pharmacological and CRISPR screens
Emanuel Gonçalves, Aldo Segura-Cabrera, Clare Pacini, Gabriele Picco, Fiona M. Behan, Patricia Jaaks, Elizabeth A. Coker, Donny van der Meer, Andrew Barthorpe, Howard Lightfoot, GDSC Screening Team, Andrew R. Leach, James T. Lynch, Ben Sidders, Claire Crafter, Francesco Iorio, Stephen Fawell, Mathew J. Garnett
bioRxiv 2020.01.14.905729; doi: https://doi.org/10.1101/2020.01.14.905729
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