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Initial virome characterization of the common cnidarian lab model Nematostella vectensis

Magda Lewandowska, Yael Hazan, View ORCID ProfileYehu Moran
doi: https://doi.org/10.1101/2020.01.14.906370
Magda Lewandowska
Department of Ecology, Evolution and Behavior, Alexander Silberman Institute of Life Sciences, Faculty of Science, The Hebrew University of Jerusalem, Jerusalem, Israel
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  • For correspondence: magda.lewandowska@mail.huji.ac.il yehu.moran@mail.huji.ac.il
Yael Hazan
Department of Ecology, Evolution and Behavior, Alexander Silberman Institute of Life Sciences, Faculty of Science, The Hebrew University of Jerusalem, Jerusalem, Israel
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Yehu Moran
Department of Ecology, Evolution and Behavior, Alexander Silberman Institute of Life Sciences, Faculty of Science, The Hebrew University of Jerusalem, Jerusalem, Israel
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  • ORCID record for Yehu Moran
  • For correspondence: magda.lewandowska@mail.huji.ac.il yehu.moran@mail.huji.ac.il
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Abstract

The role of viruses in forming a stable holobiont has been a subject of extensive research in the recent years. However, many emerging model organisms still lack any data on the composition of the associated viral communities. Here, we re-analyzed seven publicly available transcriptome datasets of the starlet sea anemone Nematostella vectensis, the most commonly used anthozoan lab model, and searched for viral sequences. We applied a straightforward, yet powerful approach of de novo assembly followed by homology-based virus identification and a multi-step, thorough taxonomic validation. The comparison of different lab populations of N. vectensis revealed the existence of the core virome composed of 21 viral sequences, present in all adult datasets. Unexpectedly, we observed almost complete lack of viruses in the samples from the early developmental stages which together with the identification of the viruses shared with the major source of the food in the lab, the brine shrimp Artemia salina, shed new light on the course of viral species acquisition in N. vectensis. Our study provides an initial, yet comprehensive insight into N. vectensis virome and sets the first foundation for functional studies of viruses and antiviral systems in this lab model cnidarian.

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Posted January 15, 2020.
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Initial virome characterization of the common cnidarian lab model Nematostella vectensis
Magda Lewandowska, Yael Hazan, Yehu Moran
bioRxiv 2020.01.14.906370; doi: https://doi.org/10.1101/2020.01.14.906370
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Initial virome characterization of the common cnidarian lab model Nematostella vectensis
Magda Lewandowska, Yael Hazan, Yehu Moran
bioRxiv 2020.01.14.906370; doi: https://doi.org/10.1101/2020.01.14.906370

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