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25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner
Man Ying Wong, Michael Lewis, James J. Doherty, Yang Shi, Patrick M. Sullivan, Mingxing Qian, Douglas F. Covey, Gregory A. Petsko, David M. Holtzman, Steven M. Paul, View ORCID ProfileWenjie Luo
doi: https://doi.org/10.1101/2020.01.14.906966
Man Ying Wong
1Appel Alzheimer’s Disease Research Institute, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, USA
Michael Lewis
2Sage Therapeutics, Cambridge, Massachusetts, USA
James J. Doherty
2Sage Therapeutics, Cambridge, Massachusetts, USA
Yang Shi
3Department of Neurology, Hope Center for Neurological Disorders, Charles F. and Joanne Knight Alzheimer’s Disease Research Center, Washington University School of Medicine, St. Louis, Missouri, USA.
Patrick M. Sullivan
4Department of Medicine, Duke University Medical Center, Durham Veterans Health Administration Medical Center’s Geriatric Research, Education and Clinical Center, Durham, NC, USA
Mingxing Qian
5Departments of Developmental Biology, Anesthesiology, Taylor Family Institute for Innovative Psychiatric Research, Washington University in St. Louis, 660 South Euclid Avenue, St. Louis, MO 63110, USA
Douglas F. Covey
5Departments of Developmental Biology, Anesthesiology, Taylor Family Institute for Innovative Psychiatric Research, Washington University in St. Louis, 660 South Euclid Avenue, St. Louis, MO 63110, USA
Gregory A. Petsko
1Appel Alzheimer’s Disease Research Institute, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, USA
David M. Holtzman
3Department of Neurology, Hope Center for Neurological Disorders, Charles F. and Joanne Knight Alzheimer’s Disease Research Center, Washington University School of Medicine, St. Louis, Missouri, USA.
Steven M. Paul
2Sage Therapeutics, Cambridge, Massachusetts, USA
6Departments of Neurology and Psychiatry, Hope Center for Neurological Disorders, Taylor Family Institute, Washington University School of Medicine, St. Louis, Missouri, USA
Wenjie Luo
1Appel Alzheimer’s Disease Research Institute, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, USA
Posted January 15, 2020.
25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner
Man Ying Wong, Michael Lewis, James J. Doherty, Yang Shi, Patrick M. Sullivan, Mingxing Qian, Douglas F. Covey, Gregory A. Petsko, David M. Holtzman, Steven M. Paul, Wenjie Luo
bioRxiv 2020.01.14.906966; doi: https://doi.org/10.1101/2020.01.14.906966
25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner
Man Ying Wong, Michael Lewis, James J. Doherty, Yang Shi, Patrick M. Sullivan, Mingxing Qian, Douglas F. Covey, Gregory A. Petsko, David M. Holtzman, Steven M. Paul, Wenjie Luo
bioRxiv 2020.01.14.906966; doi: https://doi.org/10.1101/2020.01.14.906966
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