Murine Staphylococcus aureus chronic infection is cured by theory-driven therapy

Lito A. Papaxenopoulou; Gang Zhao; Sahamoddin Khailaie; Konstantinos Katsoulis-Dimitriou; Ingo Schmitz; Eva Medina; Haralampos Hatzikirou; Michael Meyer-Hermann

doi:10.1101/2020.01.17.910786

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Murine Staphylococcus aureus chronic infection is cured by theory-driven therapy

Lito A. Papaxenopoulou, Gang Zhao, Sahamoddin Khailaie, Konstantinos Katsoulis-Dimitriou, Ingo Schmitz, Eva Medina, Haralampos Hatzikirou, Michael Meyer-Hermann

doi: https://doi.org/10.1101/2020.01.17.910786

Lito A. Papaxenopoulou

1Department of Systems Immunology and Braunschweig Integrated Centre of Systems Biology, Helmholtz Centre for Infection Research, Rebenring 56, 38106 Braunschweig, Germany

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Gang Zhao

1Department of Systems Immunology and Braunschweig Integrated Centre of Systems Biology, Helmholtz Centre for Infection Research, Rebenring 56, 38106 Braunschweig, Germany

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Sahamoddin Khailaie

1Department of Systems Immunology and Braunschweig Integrated Centre of Systems Biology, Helmholtz Centre for Infection Research, Rebenring 56, 38106 Braunschweig, Germany

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Konstantinos Katsoulis-Dimitriou

2Institute for Molecular and Clinical Immunology, Medical Faculty, Otto-von-Guericke-University, Leipziger Straße 44, 39120, Magdeburg, Germany

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Ingo Schmitz

2Institute for Molecular and Clinical Immunology, Medical Faculty, Otto-von-Guericke-University, Leipziger Straße 44, 39120, Magdeburg, Germany

3Systems-oriented Immunology and Inflammation Research Group, Department of Experimental Immunology, Helmholtz Centre for Infection Research, Inhoffenstraße 7, 38124 Braunschweig, Germany

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Eva Medina

4Department of Infection Immunology, Helmholtz Centre for Infection Research, Inhoffenstraße 7, 38124, Braunschweig, Germany

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Haralampos Hatzikirou

1Department of Systems Immunology and Braunschweig Integrated Centre of Systems Biology, Helmholtz Centre for Infection Research, Rebenring 56, 38106 Braunschweig, Germany

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For correspondence: haralampos.hatzikirou@theoretical-biology.de mmh@theoretical-biology.de

Michael Meyer-Hermann

1Department of Systems Immunology and Braunschweig Integrated Centre of Systems Biology, Helmholtz Centre for Infection Research, Rebenring 56, 38106 Braunschweig, Germany

5Institute for Biochemistry, Biotechnology and Bioinformatics, Technische Universität Braunschweig, Spielmannstraße 7, 38106 Braunschweig, Germany

6Centre for Individualised Infection Medicine (CiiM), Feodor-Lynen-Straße 15, 30625, Hannover, Germany

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For correspondence: haralampos.hatzikirou@theoretical-biology.de mmh@theoretical-biology.de

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Murine Staphylococcus aureus chronic infection is cured by theory-driven therapy

Lito A. Papaxenopoulou, Gang Zhao, Sahamoddin Khailaie, Konstantinos Katsoulis-Dimitriou, Ingo Schmitz, Eva Medina, Haralampos Hatzikirou, Michael Meyer-Hermann

bioRxiv 2020.01.17.910786; doi: https://doi.org/10.1101/2020.01.17.910786

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Murine Staphylococcus aureus chronic infection is cured by theory-driven therapy

Lito A. Papaxenopoulou, Gang Zhao, Sahamoddin Khailaie, Konstantinos Katsoulis-Dimitriou, Ingo Schmitz, Eva Medina, Haralampos Hatzikirou, Michael Meyer-Hermann

bioRxiv 2020.01.17.910786; doi: https://doi.org/10.1101/2020.01.17.910786

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