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Chinese Glioma Genome Atlas (CGGA): A Comprehensive Resource with Functional Genomic Data for Chinese Glioma Patients

View ORCID ProfileZheng Zhao, View ORCID ProfileKe’nan Zhang, View ORCID ProfileQiangwei Wang, View ORCID ProfileGuanzhang Li, View ORCID ProfileFan Zeng, View ORCID ProfileYing Zhang, View ORCID ProfileFan Wu, View ORCID ProfileRuichao Chai, View ORCID ProfileZheng Wang, View ORCID ProfileChuanbao Zhang, View ORCID ProfileWei Zhang, View ORCID ProfileZhaoshi Bao, View ORCID ProfileTao Jiang
doi: https://doi.org/10.1101/2020.01.20.911982
Zheng Zhao
1Beijing Neurosurgical Institute, Capital Medical University, Beijing 100070, China
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Ke’nan Zhang
1Beijing Neurosurgical Institute, Capital Medical University, Beijing 100070, China
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Qiangwei Wang
1Beijing Neurosurgical Institute, Capital Medical University, Beijing 100070, China
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Guanzhang Li
1Beijing Neurosurgical Institute, Capital Medical University, Beijing 100070, China
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Fan Zeng
1Beijing Neurosurgical Institute, Capital Medical University, Beijing 100070, China
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Ying Zhang
1Beijing Neurosurgical Institute, Capital Medical University, Beijing 100070, China
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Fan Wu
1Beijing Neurosurgical Institute, Capital Medical University, Beijing 100070, China
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Ruichao Chai
1Beijing Neurosurgical Institute, Capital Medical University, Beijing 100070, China
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Zheng Wang
2Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China
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Chuanbao Zhang
2Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China
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Wei Zhang
2Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China
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Zhaoshi Bao
2Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China
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  • For correspondence: taojiang1964@163.com bzsjoe1985@163.com
Tao Jiang
1Beijing Neurosurgical Institute, Capital Medical University, Beijing 100070, China
2Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China
3Center of Brain Tumour, Beijing Institute for Brain Disorders, Beijing 100069, China
4China National Clinical Research Center for Neurological Diseases, Beijing 100070, China
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  • For correspondence: taojiang1964@163.com bzsjoe1985@163.com
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Abstract

Gliomas are the most common and malignant intracranial tumours in adults. Recent studies have shown that functional genomics greatly aids in the understanding of the pathophysiology and therapy of glioma. However, comprehensive genomic data and analysis platforms are relatively limited. In this study, we developed the Chinese Glioma Genome Atlas (CGGA, http://www.cgga.org.cn), a user-friendly data portal for storage and interactive exploration of multi-dimensional functional genomic data that includes nearly 2,000 primary and recurrent glioma samples from Chinese cohorts. CGGA currently provides access to whole-exome sequencing (286 samples), messenger RNA sequencing (1,018 samples) and microarray (301 samples), DNA methylation microarray (159 samples), and microRNA microarray (198 samples) data, as well as detailed clinical data (e.g., WHO grade, histological type, critical molecular genetic information, age, sex, chemoradiotherapy status and survival data). In addition, we developed an analysis tool to allow users to browse mutational, mRNA/microRNA expression, and DNA methylation profiles and perform survival and correlation analyses of specific glioma subtypes. CGGA greatly reduces the barriers between complex functional genomic data and glioma researchers who seek rapid, intuitive, and high-quality access to data resources and enables researchers to use these immeasurable data sources for biological research and clinical application. Importantly, the free provision of data will allow researchers to quickly generate and provide data to the research community.

Footnotes

  • http://www.cgga.org.cn

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted January 21, 2020.
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Chinese Glioma Genome Atlas (CGGA): A Comprehensive Resource with Functional Genomic Data for Chinese Glioma Patients
Zheng Zhao, Ke’nan Zhang, Qiangwei Wang, Guanzhang Li, Fan Zeng, Ying Zhang, Fan Wu, Ruichao Chai, Zheng Wang, Chuanbao Zhang, Wei Zhang, Zhaoshi Bao, Tao Jiang
bioRxiv 2020.01.20.911982; doi: https://doi.org/10.1101/2020.01.20.911982
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Chinese Glioma Genome Atlas (CGGA): A Comprehensive Resource with Functional Genomic Data for Chinese Glioma Patients
Zheng Zhao, Ke’nan Zhang, Qiangwei Wang, Guanzhang Li, Fan Zeng, Ying Zhang, Fan Wu, Ruichao Chai, Zheng Wang, Chuanbao Zhang, Wei Zhang, Zhaoshi Bao, Tao Jiang
bioRxiv 2020.01.20.911982; doi: https://doi.org/10.1101/2020.01.20.911982

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