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Remodeling of pre-existing myelinated axons and oligodendrocyte differentiation is stimulated by environmental enrichment in the young adult brain

View ORCID ProfileMadeline Nicholson, Rhiannon J Wood, Jessica L Fletcher, David G Gonsalvez, Anthony J Hannan, Simon S Murray, Junhua Xiao
doi: https://doi.org/10.1101/2020.01.21.914572
Madeline Nicholson
1Neurotrophin and Myelin Laboratory, Department of Anatomy and Neuroscience, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, Victoria, 3010, Australia
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  • ORCID record for Madeline Nicholson
Rhiannon J Wood
1Neurotrophin and Myelin Laboratory, Department of Anatomy and Neuroscience, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, Victoria, 3010, Australia
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Jessica L Fletcher
1Neurotrophin and Myelin Laboratory, Department of Anatomy and Neuroscience, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, Victoria, 3010, Australia
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David G Gonsalvez
1Neurotrophin and Myelin Laboratory, Department of Anatomy and Neuroscience, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, Victoria, 3010, Australia
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Anthony J Hannan
2Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, 3010, Australia
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Simon S Murray
1Neurotrophin and Myelin Laboratory, Department of Anatomy and Neuroscience, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, Victoria, 3010, Australia
2Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, 3010, Australia
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Junhua Xiao
1Neurotrophin and Myelin Laboratory, Department of Anatomy and Neuroscience, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, Victoria, 3010, Australia
2Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, 3010, Australia
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  • For correspondence: xiaoj@unimelb.edu.au
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Article Information

doi 
https://doi.org/10.1101/2020.01.21.914572
History 
  • April 21, 2020.

Article Versions

  • Version 1 (January 23, 2020 - 03:58).
  • You are viewing Version 2, the most recent version of this article.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Madeline Nicholson1,
  2. Rhiannon J Wood1,
  3. Jessica L Fletcher1,
  4. David G Gonsalvez1,
  5. Anthony J Hannan2,
  6. Simon S Murray1,2 and
  7. Junhua Xiao1,2,*
  1. 1Neurotrophin and Myelin Laboratory, Department of Anatomy and Neuroscience, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, Victoria, 3010, Australia
  2. 2Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, 3010, Australia
  1. ↵*Corresponding author
    Dr. Junhua Xiao, Department of Anatomy and Neuroscience, The University of Melbourne, Victoria 3010, Australia, Tel: (+61 3) 9035 9759, Email: xiaoj{at}unimelb.edu.au
  1. Author contributions JX conceived the study; MN performed the experiments and analyzed data; RW, DG and JF assisted the experiments and data analysis; AH contributed to experimental design; JX and SM supervised the study; MN and JX wrote the manuscript.

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Posted April 21, 2020.
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Remodeling of pre-existing myelinated axons and oligodendrocyte differentiation is stimulated by environmental enrichment in the young adult brain
Madeline Nicholson, Rhiannon J Wood, Jessica L Fletcher, David G Gonsalvez, Anthony J Hannan, Simon S Murray, Junhua Xiao
bioRxiv 2020.01.21.914572; doi: https://doi.org/10.1101/2020.01.21.914572
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Remodeling of pre-existing myelinated axons and oligodendrocyte differentiation is stimulated by environmental enrichment in the young adult brain
Madeline Nicholson, Rhiannon J Wood, Jessica L Fletcher, David G Gonsalvez, Anthony J Hannan, Simon S Murray, Junhua Xiao
bioRxiv 2020.01.21.914572; doi: https://doi.org/10.1101/2020.01.21.914572

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