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Discovery of a novel coronavirus associated with the recent pneumonia outbreak in humans and its potential bat origin

Peng Zhou, Xing-Lou Yang, Xian-Guang Wang, Ben Hu, Lei Zhang, Wei Zhang, Hao-Rui Si, Yan Zhu, Bei Li, Chao-Lin Huang, Hui-Dong Chen, Jing Chen, Yun Luo, Hua Guo, Ren-Di Jiang, Mei-Qin Liu, Ying Chen, Xu-Rui Shen, Xi Wang, Xiao-Shuang Zheng, Kai Zhao, Quan-Jiao Chen, Fei Deng, Lin-Lin Liu, Bing Yan, Fa-Xian Zhan, Yan-Yi Wang, Gengfu Xiao, Zheng-Li Shi
doi: https://doi.org/10.1101/2020.01.22.914952
Peng Zhou
1 CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences;
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  • For correspondence: peng.zhou@wh.iov.cn
Xing-Lou Yang
1 CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences;
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  • For correspondence: yangxl@wh.iov.cn
Xian-Guang Wang
2 Wuhan Jinyintan Hospital;
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Ben Hu
1 CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences;
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  • For correspondence: huben@wh.iov.cn
Lei Zhang
1 CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences;
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  • For correspondence: zhanglei@wh.iov.cn
Wei Zhang
1 CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences;
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  • For correspondence: zhangwei@wh.iov.cn
Hao-Rui Si
1 CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences;
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  • For correspondence: sihaorui18@mails.ucas.ac.cn
Yan Zhu
1 CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences;
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  • For correspondence: zhuyan@wh.iov.cn
Bei Li
1 CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences;
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  • For correspondence: libei@wh.iov.cn
Chao-Lin Huang
2 Wuhan Jinyintan Hospital;
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Hui-Dong Chen
2 Wuhan Jinyintan Hospital;
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Jing Chen
1 CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences;
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  • For correspondence: chj911125@163.com
Yun Luo
1 CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences;
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Hua Guo
1 CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences;
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Ren-Di Jiang
1 CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences;
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  • For correspondence: drteamwind1004@163.com
Mei-Qin Liu
1 CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences;
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  • For correspondence: liumq126@163.com
Ying Chen
1 CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences;
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  • For correspondence: chenying0317@163.com
Xu-Rui Shen
1 CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences;
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  • For correspondence: pukulovesu@163.com
Xi Wang
1 CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences;
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  • For correspondence: wx_nwafu@163.com
Xiao-Shuang Zheng
1 CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences;
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  • For correspondence: xszheng@wh.iov.cn
Kai Zhao
1 CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences;
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  • For correspondence: chiukal@163.com
Quan-Jiao Chen
1 CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences;
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  • For correspondence: chenqj@wh.iov.cn
Fei Deng
3 Wuhan Institute of Virology, Chinese Academy of Sciences;
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Lin-Lin Liu
4 Hubei Provincial Center for Disease Control and Prevention
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  • For correspondence: mice0809@163.com
Bing Yan
1 CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences;
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  • For correspondence: yb@wh.iov.cn
Fa-Xian Zhan
4 Hubei Provincial Center for Disease Control and Prevention
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  • For correspondence: zhanfx@163.com
Yan-Yi Wang
1 CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences;
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Gengfu Xiao
3 Wuhan Institute of Virology, Chinese Academy of Sciences;
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Zheng-Li Shi
3 Wuhan Institute of Virology, Chinese Academy of Sciences;
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  • For correspondence: zlshi@wh.iov.cn
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Abstract

Since the SARS outbreak 18 years ago, a large number of severe acute respiratory syndrome related coronaviruses (SARSr-CoV) have been discovered in their natural reservoir host, bats. Previous studies indicated that some of those bat SARSr-CoVs have the potential to infect humans. Here we report the identification and characterization of a novel coronavirus (nCoV-2019) which caused an epidemic of acute respiratory syndrome in humans, in Wuhan, China. The epidemic, started from December 12th, 2019, has caused 198 laboratory confirmed infections with three fatal cases by January 20th, 2020. Full-length genome sequences were obtained from five patients at the early stage of the outbreak. They are almost identical to each other and share 79.5% sequence identify to SARS-CoV. Furthermore, it was found that nCoV-2019 is 96% identical at the whole genome level to a bat coronavirus. The pairwise protein sequence analysis of seven conserved non-structural proteins show that this virus belongs to the species of SARSr-CoV. The nCoV-2019 virus was then isolated from the bronchoalveolar lavage fluid of a critically ill patient, which can be neutralized by sera from several patients. Importantly, we have confirmed that this novel CoV uses the same cell entry receptor, ACE2, as SARS-CoV.

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Posted January 23, 2020.
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Discovery of a novel coronavirus associated with the recent pneumonia outbreak in humans and its potential bat origin
Peng Zhou, Xing-Lou Yang, Xian-Guang Wang, Ben Hu, Lei Zhang, Wei Zhang, Hao-Rui Si, Yan Zhu, Bei Li, Chao-Lin Huang, Hui-Dong Chen, Jing Chen, Yun Luo, Hua Guo, Ren-Di Jiang, Mei-Qin Liu, Ying Chen, Xu-Rui Shen, Xi Wang, Xiao-Shuang Zheng, Kai Zhao, Quan-Jiao Chen, Fei Deng, Lin-Lin Liu, Bing Yan, Fa-Xian Zhan, Yan-Yi Wang, Gengfu Xiao, Zheng-Li Shi
bioRxiv 2020.01.22.914952; doi: https://doi.org/10.1101/2020.01.22.914952
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Discovery of a novel coronavirus associated with the recent pneumonia outbreak in humans and its potential bat origin
Peng Zhou, Xing-Lou Yang, Xian-Guang Wang, Ben Hu, Lei Zhang, Wei Zhang, Hao-Rui Si, Yan Zhu, Bei Li, Chao-Lin Huang, Hui-Dong Chen, Jing Chen, Yun Luo, Hua Guo, Ren-Di Jiang, Mei-Qin Liu, Ying Chen, Xu-Rui Shen, Xi Wang, Xiao-Shuang Zheng, Kai Zhao, Quan-Jiao Chen, Fei Deng, Lin-Lin Liu, Bing Yan, Fa-Xian Zhan, Yan-Yi Wang, Gengfu Xiao, Zheng-Li Shi
bioRxiv 2020.01.22.914952; doi: https://doi.org/10.1101/2020.01.22.914952

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