Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Human immune system variation during one year

View ORCID ProfileTadepally Lakshmikanth, Sayyed Auwn Muhammad, Axel Olin, Yang Chen, Jaromir Mikes, Linn Fagerberg, Anders Gummesson, Göran Bergström, Mathias Uhlen, View ORCID ProfilePetter Brodin
doi: https://doi.org/10.1101/2020.01.22.915025
Tadepally Lakshmikanth
Science for Life Laboratory, Department of Women’s and Children’s Health, Karolinska Institutet, Sweden.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Tadepally Lakshmikanth
Sayyed Auwn Muhammad
Science for Life Laboratory, Department of Women’s and Children’s Health, Karolinska Institutet, Sweden.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Axel Olin
Science for Life Laboratory, Department of Women’s and Children’s Health, Karolinska Institutet, Sweden.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yang Chen
Science for Life Laboratory, Department of Women’s and Children’s Health, Karolinska Institutet, Sweden.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jaromir Mikes
Science for Life Laboratory, Department of Women’s and Children’s Health, Karolinska Institutet, Sweden.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Linn Fagerberg
Science for Life Laboratory, KTH - Royal Institute of Technology, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Anders Gummesson
Department of Molecular and Clinical Medicine, Wallenberg Laboratory, Institute of Medicine, University of GothenburgDepartment of Physiology, Sahlgrenska University Hospital, Gothenburg, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Göran Bergström
Department of Molecular and Clinical Medicine, Wallenberg Laboratory, Institute of Medicine, University of GothenburgDepartment of Physiology, Sahlgrenska University Hospital, Gothenburg, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mathias Uhlen
Science for Life Laboratory, KTH - Royal Institute of Technology, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Petter Brodin
Science for Life Laboratory, Department of Women’s and Children’s Health, Karolinska Institutet, Sweden.Department of Pediatric Rheumatology, Karolinska University Hospital, Sweden.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Petter Brodin
  • For correspondence: petter.brodin@ki.se
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Supplementary material
  • Preview PDF
Loading

SUMMARY

The human immune system varies extensively between individuals, but variation within individuals over time has not been well characterized. Systems-level analyses allow for simultaneous quantification of many interacting immune system components, and the inference of global regulatory principles. Here we present a longitudinal, systems-level analysis in 99 healthy adults, 50 to 65 years of age and sampled every 3rd month during one year. We describe the structure of inter-individual variation and characterize extreme phenotypes along a principal curve. From coordinated measurement fluctuations, we infer relationships between 115 immune cell populations and 750 plasma proteins constituting the blood immune system. While most individuals have stable immune systems, the degree of longitudinal variability is an individual feature. The most variable individuals, in the absence of overt infections, exhibited markers of poor metabolic health suggestive of a functional link between metabolic and immunologic homeostatic regulation.

HIGHLIGHTS Longitudinal variation in immune cell composition during one year

Inter-individual variation can be described along a principal curve

Immune cell and protein relationships are inferred

Variability over time is an individual feature correlating with markers of poor metabolic health

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
Back to top
PreviousNext
Posted January 23, 2020.
Download PDF

Supplementary Material

Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Human immune system variation during one year
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
Share
Human immune system variation during one year
Tadepally Lakshmikanth, Sayyed Auwn Muhammad, Axel Olin, Yang Chen, Jaromir Mikes, Linn Fagerberg, Anders Gummesson, Göran Bergström, Mathias Uhlen, Petter Brodin
bioRxiv 2020.01.22.915025; doi: https://doi.org/10.1101/2020.01.22.915025
Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
Citation Tools
Human immune system variation during one year
Tadepally Lakshmikanth, Sayyed Auwn Muhammad, Axel Olin, Yang Chen, Jaromir Mikes, Linn Fagerberg, Anders Gummesson, Göran Bergström, Mathias Uhlen, Petter Brodin
bioRxiv 2020.01.22.915025; doi: https://doi.org/10.1101/2020.01.22.915025

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Immunology
Subject Areas
All Articles
  • Animal Behavior and Cognition (1641)
  • Biochemistry (2722)
  • Bioengineering (1902)
  • Bioinformatics (10203)
  • Biophysics (4174)
  • Cancer Biology (3202)
  • Cell Biology (4522)
  • Clinical Trials (135)
  • Developmental Biology (2831)
  • Ecology (4447)
  • Epidemiology (2041)
  • Evolutionary Biology (7213)
  • Genetics (5464)
  • Genomics (6795)
  • Immunology (2380)
  • Microbiology (7462)
  • Molecular Biology (2978)
  • Neuroscience (18529)
  • Paleontology (135)
  • Pathology (472)
  • Pharmacology and Toxicology (776)
  • Physiology (1147)
  • Plant Biology (2692)
  • Scientific Communication and Education (679)
  • Synthetic Biology (885)
  • Systems Biology (2840)
  • Zoology (465)