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Independent evolution of transcript abundance and gene regulatory dynamics

Gat Krieger, Offir Lupo, Avraham A. Levy, Naama Barkai
doi: https://doi.org/10.1101/2020.01.22.915033
Gat Krieger
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, IsraelDepartment of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot 76100, Israel
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Offir Lupo
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
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Avraham A. Levy
Department of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot 76100, Israel
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Naama Barkai
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
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  • For correspondence: naama.barkai@weizmann.ac.il
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Abstract

Changes in gene expression drive novel phenotypes, raising interest in how gene expression evolves. In contrast to the static genome, cells regulate gene expression to accommodate changing conditions. Previous comparative studies focused on specific conditions, describing inter-species variation in expression levels, but providing limited information about variations in gene regulation. To close this gap, we profiled gene expression of related yeast species in hundreds of conditions, and used co-expression analysis to distinguish variations in transcription regulation from variations in expression levels or environmental perception. The majority of genes whose expression varied between the species maintained a conserved transcriptional regulation. Profiling the interspecific hybrid provided insights into the basis of variations, showed that trans-varying alleles interact dominantly, and revealed complementation of cis-variations by variations in trans. Our data suggests that gene expression diverges primarily through changes in promoter strength that do not alter gene positioning within the transcription network.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted January 23, 2020.
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Independent evolution of transcript abundance and gene regulatory dynamics
Gat Krieger, Offir Lupo, Avraham A. Levy, Naama Barkai
bioRxiv 2020.01.22.915033; doi: https://doi.org/10.1101/2020.01.22.915033
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Independent evolution of transcript abundance and gene regulatory dynamics
Gat Krieger, Offir Lupo, Avraham A. Levy, Naama Barkai
bioRxiv 2020.01.22.915033; doi: https://doi.org/10.1101/2020.01.22.915033

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