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Independent representations of reward-predicting cues and reward history in frontal cortical neurons

View ORCID ProfileMasashi Kondo, Masanori Matsuzaki
doi: https://doi.org/10.1101/2020.01.23.916460
Masashi Kondo
1Department of Physiology, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-0033, Japan
2JSPS Research Fellow, Japan Society for the Promotion of Science, Tokyo, 102-0083, Japan
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  • ORCID record for Masashi Kondo
Masanori Matsuzaki
1Department of Physiology, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-0033, Japan
3International Research Center for Neurointelligence (WPI-IRCN), The University of Tokyo Institutes for Advanced Study, Tokyo, 113-0033, Japan
4Brain Functional Dynamics Collaboration Laboratory, RIKEN Center for Brain Science, Saitama 351-0198, Japan
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  • For correspondence: mzakim@m.u-tokyo.ac.jp
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Summary

The transformation of sensory inputs to appropriate goal-directed actions requires estimation of sensory-cue values based on outcome history. To clarify how cortical neurons represent an outcome-predicting cue and actual outcome, we conducted wide-field and two-photon calcium imaging of the mouse neocortex during performance of a classical conditioning task with two cues with different water-reward probabilities. Although licking behavior dominated the area-averaged activity over the whole dorsal neocortex, dorsomedial frontal cortex (dmFrC) affected other dorsal frontal cortical activities, and its inhibition extinguished differences in anticipatory licking between the cues. In individual frontal cortical neurons, the reward-predicting cue was not simultaneously represented with the current or past reward, but licking behavior was frequently multiplexed with the reward-predicting cue and current or past reward. Deep-layer neurons in dmFrC most strongly represented the reward-predicting cue and recent reward history. Our results suggest that these neurons ignite the cortical processes required to select appropriate actions.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted January 24, 2020.
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Independent representations of reward-predicting cues and reward history in frontal cortical neurons
Masashi Kondo, Masanori Matsuzaki
bioRxiv 2020.01.23.916460; doi: https://doi.org/10.1101/2020.01.23.916460
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Independent representations of reward-predicting cues and reward history in frontal cortical neurons
Masashi Kondo, Masanori Matsuzaki
bioRxiv 2020.01.23.916460; doi: https://doi.org/10.1101/2020.01.23.916460

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