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The 2019-new coronavirus epidemic: evidence for virus evolution

Domenico Benvenuto, Marta Giovannetti, Alessandra Ciccozzi, Silvia Spoto, Silvia Angeletti, Massimo Ciccozzi
doi: https://doi.org/10.1101/2020.01.24.915157
Domenico Benvenuto
1Unit of Medical Statistics and Molecular Epidemiology, University Campus Bio-Medico of Rome, Italy
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Marta Giovannetti
2Laboratório de Flavivírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil
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Alessandra Ciccozzi
1Unit of Medical Statistics and Molecular Epidemiology, University Campus Bio-Medico of Rome, Italy
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Silvia Spoto
3Internal Medicine Unit, University Campus Bio-Medico of Rome, Italy
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Silvia Angeletti
4Unit of Clinical Laboratory Science, University Campus Bio-Medico of Rome, Italy
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  • For correspondence: s.angeletti@unicampus.it
Massimo Ciccozzi
2Laboratório de Flavivírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil
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Abstract

There is concern about a new coronavirus, the 2019-nCoV, as a global public health threat. In this article, we provide a preliminary evolutionary and molecular epidemiological analysis of this new virus. A phylogenetic tree has been built using the 15 available whole genome sequence of 2019-nCoV and 12 whole genome sequences highly similar sequences available in gene bank (5 from SARS, 2 from MERS and 5 from Bat SARS-like Coronavirus). FUBAR analysis shows that the Nucleocapsid and the Spike Glycoprotein has some sites under positive pressure while homology modelling helped to explain some molecular and structural differences between the viruses. The phylogenetic tree showed that 2019.nCoV significantly clustered with Bat SARS-like Coronavirus sequence isolated in 2015, whereas structural analysis revealed mutation in S and nucleocapsid proteins. From these results, 2019nCoV could be considered a coronavirus distinct from SARS virus, probably transmitted from bats or another host where mutations conferred upon it the ability to infect humans.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted January 24, 2020.
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The 2019-new coronavirus epidemic: evidence for virus evolution
Domenico Benvenuto, Marta Giovannetti, Alessandra Ciccozzi, Silvia Spoto, Silvia Angeletti, Massimo Ciccozzi
bioRxiv 2020.01.24.915157; doi: https://doi.org/10.1101/2020.01.24.915157
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The 2019-new coronavirus epidemic: evidence for virus evolution
Domenico Benvenuto, Marta Giovannetti, Alessandra Ciccozzi, Silvia Spoto, Silvia Angeletti, Massimo Ciccozzi
bioRxiv 2020.01.24.915157; doi: https://doi.org/10.1101/2020.01.24.915157

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