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Ameliorative effect of a quinazoline-based bromodomain inhibitor, CN210, on experimentally-induced Crohn’s disease-like murine ileitis via inhibition of inflammatory cytokine expression

Takehisa Noguchi, Kyosuke Hidaka, Satsuki Kobayashi, Kenjiro Matsumoto, Makoto Yoshioka, Shyh-Ming Yang, David J. Maloney, View ORCID ProfileShinichi Kato
doi: https://doi.org/10.1101/2020.01.24.917948
Takehisa Noguchi
1Division of Pathological Sciences, Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Kyoto, Japan
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Kyosuke Hidaka
1Division of Pathological Sciences, Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Kyoto, Japan
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Satsuki Kobayashi
1Division of Pathological Sciences, Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Kyoto, Japan
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Kenjiro Matsumoto
1Division of Pathological Sciences, Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Kyoto, Japan
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Makoto Yoshioka
2ConverGene LLC, 3093 Beverly Lane, Unit C, Cambridge, MD 21613, USA
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Shyh-Ming Yang
3National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD 20850, USA
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David J. Maloney
3National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD 20850, USA
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Shinichi Kato
1Division of Pathological Sciences, Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Kyoto, Japan
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  • ORCID record for Shinichi Kato
  • For correspondence: skato@mb.kyoto-phu.ac.jp
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Article Information

doi 
https://doi.org/10.1101/2020.01.24.917948
History 
  • January 24, 2020.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.

Author Information

  1. Takehisa Noguchi1,¶,
  2. Kyosuke Hidaka1,¶,
  3. Satsuki Kobayashi1,¶,
  4. Kenjiro Matsumoto1,
  5. Makoto Yoshioka2,
  6. Shyh-Ming Yang3,
  7. David J. Maloney3 and
  8. Shinichi Kato1,*
  1. 1Division of Pathological Sciences, Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Kyoto, Japan
  2. 2ConverGene LLC, 3093 Beverly Lane, Unit C, Cambridge, MD 21613, USA
  3. 3National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD 20850, USA
  1. ↵*Corresponding author: Email: skato{at}mb.kyoto-phu.ac.jp (SK)
  1. ↵¶ These authors contributed equally to this work

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Posted January 24, 2020.
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Ameliorative effect of a quinazoline-based bromodomain inhibitor, CN210, on experimentally-induced Crohn’s disease-like murine ileitis via inhibition of inflammatory cytokine expression
Takehisa Noguchi, Kyosuke Hidaka, Satsuki Kobayashi, Kenjiro Matsumoto, Makoto Yoshioka, Shyh-Ming Yang, David J. Maloney, Shinichi Kato
bioRxiv 2020.01.24.917948; doi: https://doi.org/10.1101/2020.01.24.917948
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Ameliorative effect of a quinazoline-based bromodomain inhibitor, CN210, on experimentally-induced Crohn’s disease-like murine ileitis via inhibition of inflammatory cytokine expression
Takehisa Noguchi, Kyosuke Hidaka, Satsuki Kobayashi, Kenjiro Matsumoto, Makoto Yoshioka, Shyh-Ming Yang, David J. Maloney, Shinichi Kato
bioRxiv 2020.01.24.917948; doi: https://doi.org/10.1101/2020.01.24.917948

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