Abstract
Colorectal cancer is one of the leading causes of cancer death worldwide. Patients’ survival at the time of diagnosis depends largely on the stage of the tumor. Therefore, understanding the molecular mechanisms promoting cancer progression from early stages to high-grade stages is essential for implementing therapeutic approaches. In the present study, we conducted transcriptomic data analysis employing a systems biology method to identify potential molecular targets for colorectal cancer treatment. These targets went under investigation one by one. We proposed some genes that their expression induction or suppression alone or in combination with each other would inhibit tumor progression or metastasis based on their biological activity. They are involved in cell proliferation, energy production under hypoxic conditions, epithelial to mesenchymal transition (EMT) and angiogenesis. Employing a network analysis point of view, some genes were discovered that has not been reported noticeably in any kind of cancer so far. As a result, they might have some roles in progression of colorectal cancer.