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Different forms of fear extinction are supported by distinct cortical substrates

Belinda Lay, Audrey A. Pitaru, Nathan Boulianne, Guillem R Esber, View ORCID ProfileMihaela D Iordanova
doi: https://doi.org/10.1101/2020.01.27.921221
Belinda Lay
Concordia University;
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  • For correspondence: b.lay1690@gmail.com
Audrey A. Pitaru
Concordia University;
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  • For correspondence: a-pitaru@hotmail.com
Nathan Boulianne
Concordia University;
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  • For correspondence: n.bouliannework@gmail.com
Guillem R Esber
National Institute on Drug Abuse
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  • For correspondence: goresber@gmail.com
Mihaela D Iordanova
Concordia University;
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  • ORCID record for Mihaela D Iordanova
  • For correspondence: mihaela.iordanova@concordia.ca
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Abstract

Understanding how learned fear can be reduced is at the heart of treatments for anxiety disorders. Tremendous progress has been made in this regard through extinction training in which the aversive outcome is omitted. However, current progress almost entirely rests on this single paradigm, resulting in a very specialized knowledgebase at the behavioural and neural level of analysis. Here, we used a paradigm-independent approach to show that different methods that lead to reduction in learned fear are dissociated in the cortex. We report that the infralimbic cortex has a very specific role in fear reduction that depends on the omission of aversive events but not on overexpectation. The orbitofrontal cortex, a structure generally overlooked in fear, is critical for downregulating fear when fear is inflated or overexpected, but not when an aversive event is omitted.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted January 28, 2020.
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Different forms of fear extinction are supported by distinct cortical substrates
Belinda Lay, Audrey A. Pitaru, Nathan Boulianne, Guillem R Esber, Mihaela D Iordanova
bioRxiv 2020.01.27.921221; doi: https://doi.org/10.1101/2020.01.27.921221
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Different forms of fear extinction are supported by distinct cortical substrates
Belinda Lay, Audrey A. Pitaru, Nathan Boulianne, Guillem R Esber, Mihaela D Iordanova
bioRxiv 2020.01.27.921221; doi: https://doi.org/10.1101/2020.01.27.921221

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