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A cell atlas of human thymic development defines T cell repertoire formation
View ORCID ProfileJong-Eun Park, Rachel A. Botting, View ORCID ProfileCecilia Domínguez Conde, Dorin-Mirel Popescu, Marieke Lavaert, Daniel J. Kunz, Emily Stephenson, Roberta Ragazzini, Elizabeth Tuck, Anna Wilbrey-Clark, View ORCID ProfileJohn R. Ferdinand, Simone Webb, Daniel Maunder, Niels Vandamme, Krishnaa Mahbubani, Krzysztof Polanski, Lira Mamanova, Andrew Fuller, Andrew Filby, Gary Reynolds, David Dixon, Kourosh Saeb-Parsy, Steven Lisgo, Deborah Henderson, Roser Vento-Tormo, View ORCID ProfileKerstin B. Meyer, Yvan Saeys, Paola Bonfanti, Sam Behjati, Menna R. Clatworthy, Tom Taghon, Muzlifah Haniffa, View ORCID ProfileSarah A. Teichmann
doi: https://doi.org/10.1101/2020.01.28.911115
Jong-Eun Park
1Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK
Rachel A. Botting
2Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK
Cecilia Domínguez Conde
1Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK
Dorin-Mirel Popescu
2Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK
Marieke Lavaert
3Faculty of Medicine and Health Sciences, Department of Diagnostic Sciences, Ghent University, C. Heymanslaan 10, MRB2, Entrance 38, 9000 Ghent, Belgium
4Cancer Research Institute Ghent (CRIG), Ghent University, Ghent, Belgium
Daniel J. Kunz
1Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK
19Theory of Condensed Matter Group, Cavendish Laboratory/Department of Physics, University of Cambridge, Cambridge CB3 0HE, UK
20The Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, United Kingdom
Emily Stephenson
2Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK
Roberta Ragazzini
9The Francis Crick Institute, London, UK
Elizabeth Tuck
1Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK
Anna Wilbrey-Clark
1Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK
John R. Ferdinand
5Molecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, United Kingdom, CB2 0QQ
Simone Webb
3Faculty of Medicine and Health Sciences, Department of Diagnostic Sciences, Ghent University, C. Heymanslaan 10, MRB2, Entrance 38, 9000 Ghent, Belgium
Daniel Maunder
3Faculty of Medicine and Health Sciences, Department of Diagnostic Sciences, Ghent University, C. Heymanslaan 10, MRB2, Entrance 38, 9000 Ghent, Belgium
Niels Vandamme
6Data Mining and Modeling for Biomedicine, VIB Center for Inflammation Research, Ghent, Belgium
21Department of Applied Mathematics, Computer Science and Statistics, Ghent University, Ghent, Belgium
Krishnaa Mahbubani
7Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, United Kingdom, CB2 0QQ
Krzysztof Polanski
1Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK
Lira Mamanova
1Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK
Andrew Fuller
2Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK
Andrew Filby
2Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK
Gary Reynolds
2Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK
David Dixon
2Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK
Kourosh Saeb-Parsy
7Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, United Kingdom, CB2 0QQ
Steven Lisgo
8Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, NE1 3BZ, UK
Deborah Henderson
8Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, NE1 3BZ, UK
Roser Vento-Tormo
1Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK
Kerstin B. Meyer
1Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK
Yvan Saeys
6Data Mining and Modeling for Biomedicine, VIB Center for Inflammation Research, Ghent, Belgium
21Department of Applied Mathematics, Computer Science and Statistics, Ghent University, Ghent, Belgium
Paola Bonfanti
9The Francis Crick Institute, London, UK
10Great Ormond Street Institute of Child Health, University College London, London, UK
11Institute of Immunity and Transplantation, University College London, London, UK
Sam Behjati
22Department of Haematology and Wellcome and MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, CB2 2XY, UK
23Department of Paediatrics, University of Cambridge, Cambridge CB2 0SP, UK
Menna R. Clatworthy
5Molecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, United Kingdom, CB2 0QQ
12Cambridge University Hospitals NHS Foundation Trust, United Kingdom, CB2 0QQ
Tom Taghon
3Faculty of Medicine and Health Sciences, Department of Diagnostic Sciences, Ghent University, C. Heymanslaan 10, MRB2, Entrance 38, 9000 Ghent, Belgium
4Cancer Research Institute Ghent (CRIG), Ghent University, Ghent, Belgium
Muzlifah Haniffa
1Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK
2Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK
13Department of Dermatology and NIHR Newcastle Biomedical Research Centre, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne NE2 4LP, UK
Sarah A. Teichmann
1Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK
19Theory of Condensed Matter Group, Cavendish Laboratory/Department of Physics, University of Cambridge, Cambridge CB3 0HE, UK
Article usage
Posted January 28, 2020.
A cell atlas of human thymic development defines T cell repertoire formation
Jong-Eun Park, Rachel A. Botting, Cecilia Domínguez Conde, Dorin-Mirel Popescu, Marieke Lavaert, Daniel J. Kunz, Emily Stephenson, Roberta Ragazzini, Elizabeth Tuck, Anna Wilbrey-Clark, John R. Ferdinand, Simone Webb, Daniel Maunder, Niels Vandamme, Krishnaa Mahbubani, Krzysztof Polanski, Lira Mamanova, Andrew Fuller, Andrew Filby, Gary Reynolds, David Dixon, Kourosh Saeb-Parsy, Steven Lisgo, Deborah Henderson, Roser Vento-Tormo, Kerstin B. Meyer, Yvan Saeys, Paola Bonfanti, Sam Behjati, Menna R. Clatworthy, Tom Taghon, Muzlifah Haniffa, Sarah A. Teichmann
bioRxiv 2020.01.28.911115; doi: https://doi.org/10.1101/2020.01.28.911115
A cell atlas of human thymic development defines T cell repertoire formation
Jong-Eun Park, Rachel A. Botting, Cecilia Domínguez Conde, Dorin-Mirel Popescu, Marieke Lavaert, Daniel J. Kunz, Emily Stephenson, Roberta Ragazzini, Elizabeth Tuck, Anna Wilbrey-Clark, John R. Ferdinand, Simone Webb, Daniel Maunder, Niels Vandamme, Krishnaa Mahbubani, Krzysztof Polanski, Lira Mamanova, Andrew Fuller, Andrew Filby, Gary Reynolds, David Dixon, Kourosh Saeb-Parsy, Steven Lisgo, Deborah Henderson, Roser Vento-Tormo, Kerstin B. Meyer, Yvan Saeys, Paola Bonfanti, Sam Behjati, Menna R. Clatworthy, Tom Taghon, Muzlifah Haniffa, Sarah A. Teichmann
bioRxiv 2020.01.28.911115; doi: https://doi.org/10.1101/2020.01.28.911115
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