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Hierarchical Network Model Excitatory-Inhibitory Tone Shapes Alternative Strategies for Different Degrees of Uncertainty in Multi-Attribute Decisions

View ORCID ProfileWarren Woodrich Pettine, View ORCID ProfileKenway Louie, John D Murray, View ORCID ProfileXiao Jing Wang
doi: https://doi.org/10.1101/2020.01.28.923649
Warren Woodrich Pettine
Center for Neural Science, New York University, New York, NY 10003, USA
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Kenway Louie
Center for Neural Science, New York University, New York, NY 10003, USA
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John D Murray
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06510
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Xiao Jing Wang
Center for Neural Science, New York University, New York, NY 10003, USA
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  • For correspondence: xjwang@nyu.edu
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Abstract

We investigated two-attribute, two-alternative decision-making in a hierarchical neural network with three layers: an input layer encoding choice alternative attribute values; an intermediate layer of modules processing separate attributes; and a choice layer producing the decision. Depending on intermediate layer excitatory-inhibitory (E/I) tone, the network displays three distinct regimes characterized by linear (I), convex (II) or concave (III) choice indifference curves. In regimes I and II, each option’s attribute information is additively integrated. To maximize reward at low environmental uncertainty, the system should operate in regime I. At high environmental uncertainty, reward maximization is achieved in regime III, with each attribute module selecting a favored alternative, and the ultimate decision based upon comparison between outputs of attribute processing modules. We then use these principles to examine multi-attribute decisions with autism-related deficits in E/I balance, leading to predictions of different choice patterns and overall performance between autism and neurotypicals.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license.
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Posted January 29, 2020.
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Hierarchical Network Model Excitatory-Inhibitory Tone Shapes Alternative Strategies for Different Degrees of Uncertainty in Multi-Attribute Decisions
Warren Woodrich Pettine, Kenway Louie, John D Murray, Xiao Jing Wang
bioRxiv 2020.01.28.923649; doi: https://doi.org/10.1101/2020.01.28.923649
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Hierarchical Network Model Excitatory-Inhibitory Tone Shapes Alternative Strategies for Different Degrees of Uncertainty in Multi-Attribute Decisions
Warren Woodrich Pettine, Kenway Louie, John D Murray, Xiao Jing Wang
bioRxiv 2020.01.28.923649; doi: https://doi.org/10.1101/2020.01.28.923649

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