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Prefrontal state fluctuations control access to consciousness

Abhilash Dwarakanath, Vishal Kapoor, Joachim Werner, Shervin Safavi, Leonid A. Fedorov, Nikos K. Logothetis, Theofanis I. Panagiotaropoulos
doi: https://doi.org/10.1101/2020.01.29.924928
Abhilash Dwarakanath
1Department of Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Tübingen 72076, Germany
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  • For correspondence: abhilash.dwarakanath@tuebingen.mpg.de theofanis.panagiotaropoulos@tuebingen.mpg.de
Vishal Kapoor
1Department of Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Tübingen 72076, Germany
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Joachim Werner
1Department of Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Tübingen 72076, Germany
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Shervin Safavi
1Department of Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Tübingen 72076, Germany
2International Max Planck Research School, Tübingen 72076, Germany
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Leonid A. Fedorov
1Department of Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Tübingen 72076, Germany
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Nikos K. Logothetis
1Department of Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Tübingen 72076, Germany
3Division of Imaging Science and Biomedical Engineering, University of Manchester, Manchester M13 9PT, UK
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Theofanis I. Panagiotaropoulos
1Department of Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Tübingen 72076, Germany
4Cognitive Neuroimaging Unit, CEA, DSV/I2BM, INSERM, Universite Paris-Sud, Universite Paris-Saclay, Neurospin Center, 91191 Gif/Yvette, France
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Abstract

In perceptual multistability, the content of consciousness alternates spontaneously between different interpretations of unchanged sensory input. The source of these internally driven transitions in conscious perception is unknown. Here we show that transient, low frequency (1-9 Hz) perisynaptic bursts in the macaque lateral prefrontal cortex precede spontaneous perceptual transitions in a no-report binocular motion rivalry task. These low-frequency transients suppress 20-40 Hz oscillatory bursts that selectively synchronise the discharge activity of neuronal ensembles signalling conscious content. Similar ongoing state changes, with dynamics resembling the temporal structure of spontaneous perceptual alternations during rivalry, dominate the prefrontal cortex during resting-state, thus pointing to their default, endogenous nature. Our results suggest that prefrontal state fluctuations control access to consciousness through a reorganisation in the activity of feature-specific neuronal ensembles.

One sentence summary Prefrontal state transitions precede spontaneous transitions in the content of consciousness.

Footnotes

  • ↵§ Co-senior authors

  • Updated SI Figure 11, fixed grammar, typos and syntax

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted February 04, 2020.
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Prefrontal state fluctuations control access to consciousness
Abhilash Dwarakanath, Vishal Kapoor, Joachim Werner, Shervin Safavi, Leonid A. Fedorov, Nikos K. Logothetis, Theofanis I. Panagiotaropoulos
bioRxiv 2020.01.29.924928; doi: https://doi.org/10.1101/2020.01.29.924928
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Prefrontal state fluctuations control access to consciousness
Abhilash Dwarakanath, Vishal Kapoor, Joachim Werner, Shervin Safavi, Leonid A. Fedorov, Nikos K. Logothetis, Theofanis I. Panagiotaropoulos
bioRxiv 2020.01.29.924928; doi: https://doi.org/10.1101/2020.01.29.924928

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