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The digestive system is a potential route of 2019-nCov infection: a bioinformatics analysis based on single-cell transcriptomes

Hao Zhang, Zijian Kang, Haiyi Gong, Da Xu, Jing Wang, Zifu Li, Xingang Cui, Jianru Xiao, Tong Meng, Wang Zhou, Jianmin Liu, Huji Xu
doi: https://doi.org/10.1101/2020.01.30.927806
Hao Zhang
1Department of Rheumatology and Immunology, Changzheng Hospital, Second Military Medical University, 200003 Shanghai, China
4Department of Orthopaedic Oncology, Changzheng Hospital, Second Military Medical University, 200003 Shanghai, China
9Qiu-Jiang Bioinformatics Institute, 200003 Shanghai, China
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Zijian Kang
1Department of Rheumatology and Immunology, Changzheng Hospital, Second Military Medical University, 200003 Shanghai, China
9Qiu-Jiang Bioinformatics Institute, 200003 Shanghai, China
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Haiyi Gong
4Department of Orthopaedic Oncology, Changzheng Hospital, Second Military Medical University, 200003 Shanghai, China
9Qiu-Jiang Bioinformatics Institute, 200003 Shanghai, China
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Da Xu
6Depanrtment of Urology, The Third Affiliated Hospital of Second Military Medical University, 201805 Shanghai, China
9Qiu-Jiang Bioinformatics Institute, 200003 Shanghai, China
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Jing Wang
5Department of Neurosurgery, Changhai Hospital, Second Military Medical University, 200003 Shanghai, China
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Zifu Li
5Department of Neurosurgery, Changhai Hospital, Second Military Medical University, 200003 Shanghai, China
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Xingang Cui
6Depanrtment of Urology, The Third Affiliated Hospital of Second Military Medical University, 201805 Shanghai, China
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Jianru Xiao
4Department of Orthopaedic Oncology, Changzheng Hospital, Second Military Medical University, 200003 Shanghai, China
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Tong Meng
7Division of Spine, Department of Orthopedics, Tongji Hospital affiliated to Tongji University School of Medicine, 200065 Shanghai, China
8Tongji University Cancer Center, School of Medicine, Tongji University, 200092 Shanghai, China
9Qiu-Jiang Bioinformatics Institute, 200003 Shanghai, China
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  • For correspondence: huji_xu@tsinghua.edu.cn chstroke@163.com brilliant212@163.com mengtong@medmail.com.cn
Wang Zhou
2Peking-Tsinghua Center for Life Sciences, TsinghuaUniversity, Beijing, P.R. China
9Qiu-Jiang Bioinformatics Institute, 200003 Shanghai, China
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  • For correspondence: huji_xu@tsinghua.edu.cn chstroke@163.com brilliant212@163.com mengtong@medmail.com.cn
Jianmin Liu
5Department of Neurosurgery, Changhai Hospital, Second Military Medical University, 200003 Shanghai, China
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  • For correspondence: huji_xu@tsinghua.edu.cn chstroke@163.com brilliant212@163.com mengtong@medmail.com.cn
Huji Xu
1Department of Rheumatology and Immunology, Changzheng Hospital, Second Military Medical University, 200003 Shanghai, China
2Peking-Tsinghua Center for Life Sciences, TsinghuaUniversity, Beijing, P.R. China
3Beijing Tsinghua Changgeng Hospital, School of Clinical Medicine, Tsinghua University, 100084 Beijing, China
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  • For correspondence: huji_xu@tsinghua.edu.cn chstroke@163.com brilliant212@163.com mengtong@medmail.com.cn
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Abstract

Since December 2019, a newly identified coronavirus (2019 novel coronavirus, 2019-nCov) is causing outbreak of pneumonia in one of largest cities, Wuhan, in Hubei province of China and has draw significant public health attention. The same as severe acute respiratory syndrome coronavirus (SARS-CoV), 2019-nCov enters into host cells via cell receptor angiotensin converting enzyme II (ACE2). In order to dissect the ACE2-expressing cell composition and proportion and explore a potential route of the 2019-nCov infection in digestive system infection, 4 datasets with single-cell transcriptomes of lung, esophagus, gastric, ileum and colon were analyzed. The data showed that ACE2 was not only highly expressed in the lung AT2 cells, esophagus upper and stratified epithelial cells but also in absorptive enterocytes from ileum and colon. These results indicated along with respiratory systems, digestive system is a potential routes for 2019-nCov infection. In conclusion, this study has provided the bioinformatics evidence of the potential route for infection of 2019-nCov in digestive system along with respiratory tract and may have significant impact for our healthy policy setting regards to prevention of 2019-nCoV infection.

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Posted January 31, 2020.
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The digestive system is a potential route of 2019-nCov infection: a bioinformatics analysis based on single-cell transcriptomes
Hao Zhang, Zijian Kang, Haiyi Gong, Da Xu, Jing Wang, Zifu Li, Xingang Cui, Jianru Xiao, Tong Meng, Wang Zhou, Jianmin Liu, Huji Xu
bioRxiv 2020.01.30.927806; doi: https://doi.org/10.1101/2020.01.30.927806
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The digestive system is a potential route of 2019-nCov infection: a bioinformatics analysis based on single-cell transcriptomes
Hao Zhang, Zijian Kang, Haiyi Gong, Da Xu, Jing Wang, Zifu Li, Xingang Cui, Jianru Xiao, Tong Meng, Wang Zhou, Jianmin Liu, Huji Xu
bioRxiv 2020.01.30.927806; doi: https://doi.org/10.1101/2020.01.30.927806

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