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History
- February 3, 2020.
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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license.
Author Information
- Puya Gharahkhani1,*,&,
- Eric Jorgenson2,*,
- Pirro Hysi3,*,
- Anthony P. Khawaja4,5,*,
- Sarah Pendergrass6,*,
- Xikun Han1,
- Jue Sheng Ong1,
- Alex W. Hewitt7,8,
- Ayellet Segre9,
- Robert P. Igo Jr10,
- Helene Choquet2,
- Ayub Qassim11,
- Navya S Josyula12,
- Jessica N. Cooke Bailey10,13,
- Pieter Bonnemaijer14,15,16,
- Adriana Iglesias14,15,17,
- Owen M. Siggs11,
- Terri Young18,
- Veronique Vitart19,
- Alberta A.H.J. Thiadens14,15,
- Juha Karjalainen20,21,22,
- Steffen Uebe23,
- Ronald B. Melles24,
- K. Saidas Nair25,
- Robert Luben5,
- Mark Simcoe3,
- Nishani Amersinghe26,
- Angela J. Cree27,
- Rene Hohn28,29,
- Alicia Poplawski30,
- Li Jia Chen (CUHK)31,
- Ching-Yu Cheng32,33,34,
- Eranga Nishanthie Vithana32,35,
- NEIGHBORHOOD consortium,
- ANZRAG consortium,
- Biobank Japan project,
- FinnGen study,
- UK Biobank Eye and Vision Consortium,
- GIGA study group,
- 23andMe Research Team,
- Gen Tamiya36,37,
- Yukihiro Shiga38,
- Masayuki Yamamoto36,
- Toru Nakazawa38,39,40,41,
- John Rouhana9,
- Hannah Currant42,
- Ewan Birney42,
- Xin Wang43,
- Adam Auton43,
- Adeyinka Ashaye44,
- Olusola Olawoye44,
- Susan E. Williams45,
- Stephen Akafo46,
- Michele Ramsay47,
- Kazuki Hashimoto38,
- Yoichito Kamatani48,49,
- Masato Akiama48,50,
- Yukihide Momozawa51,
- Paul J. Foster52,53,
- Peng T. Khaw52,53,
- James E. Morgan54,
- Nicholas G. Strouthidis52,53,
- Peter Kraft55,
- Jae Hee Kang56,
- Calvin Chi Pui Pang (CUHK)57,
- Francesca Pasutto23,
- Paul Mitchell58,
- Andrew J. Lotery26,
- Aarno Palotie59,60,61,
- Cornelia van Duijn15,
- Jonathan Haines10,13,
- Chris Hammond3,
- Louis R. Pasquale62,
- Caroline C.W. Klaver14,15,63,64,
- Michael Hauser65,66,67,
- Chiea Chuen Khor68,
- David A. Mackey69,8,7,
- Michiaki Kubo70,#,
- Tin Aung32,33,34,#,
- Jamie Craig71,#,
- Stuart MacGregor1,# and
- Janey Wiggs9,#
- 1QIMR Berghofer Medical Research Institute, Brisbane, Queensland, 4029, Australia
- 2Division of Research, Kaiser Permanente Northern California (KPNC), Oakland, CA 94612, USA
- 3Twin Research and Genetic Epidemiology, King’s College London, London, UK
- 4NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK
- 5Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge School of Clinical Medicine, Cambridge, UK
- 6Geisinger Research, Biomedical and Translational Informatics Institute, Danville, PA, USA
- 7Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia
- 8Centre for Eye Research Australia, University of Melbourne, Melbourne, Victoria, Australia
- 9Department of Ophthalmology, Harvard Medical School, Boston, Mass USA 02114
- 10Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106
- 11Department of Ophthalmology, Flinders University, Bedford Park, South Australia, Australia
- 12Geisinger Research, Biomedical and Translational Informatics Institute, Rockville, MD, USA
- 13Cleveland Institute for Computational Biology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106
- 14Depatment of Ophthalmology, Erasmus MC, Rotterdam, The Netherlands
- 15Department of Epidemiology, Erasmus MC Rotterdam, The Netherlands
- 16The Rotterdam Eye Hospital, Rotterdam, The Netherlands
- 17Department of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands
- 18Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States
- 19Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK
- 20Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland
- 21Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA
- 22Analytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
- 23Institute of Human Genetics, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität, Erlangen-Nürnberg, Erlangen, Germany
- 24Department of Ophthalmology, KPNC, Redwood City, CA 94063, USA
- 25Department of Ophthalmology, and Department of Anatomy, School of Medicine, University of California San Francisco (UCSF), San Francisco, CA 94143, USA
- 26University Hospital Southampton NHS Foundation Trust, Southampton, UK
- 27Faculty of Medicine, University of Southampton, Southampton, UK
- 28Department of Ophthalmology, Inselspital, University Hospital Bern, University of Bern, Bern, Germany
- 29Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany
- 30IMBEI Institute of Medical Biostatistics, Epidemiology and Informatics University Medicine of the Johannes Gutenberg University, Mainz, Germany
- 31The Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong
- 32Singapore Eye Research Institute, Singapore National Eye Certre, Singapore 169856, Singapore
- 33Ophthalmology & Visual Sciences Academic Clinical Program, Duke-NUS Medical School, Singapore 169857, Singapore
- 34Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore
- 35Duke-National University of Singapore Medical School, Singapore, Republic of Singapore
- 36Tohoku Medical Megabank Organization, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan
- 37RIKEN Center for Advanced Intelligence Project, 1-4-1 Nihonbashi, Chuo-ku, Tokyo 103-0027, Japan
- 38Department of Ophthalmology, Tohoku University Graduate School of Medicine, 1-1, Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan
- 39Department of Retinal Disease Control, Tohoku University Graduate School of Medicine, 1-1, Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan
- 40Department of Advanced Ophthalmic Medicine, Tohoku University Graduate School of Medicine, 1-1, Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan,
- 41Department of Ophthalmic Imaging and Information Analytics, Tohoku University Graduate School of Medicine, 1-1, Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan
- 42European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom,
- 4323andMe Inc., San Francisco, California, USA
- 44Department of Ophthalmology, University of Ibadan, Ibadan, Nigeria
- 45Division of Ophthalmology, Department of Neurosciences, University of the Witwatersrand, Johannesburg, South Africa
- 46Unit of Ophthalmology, Department of Surgery, University of Ghana Medical School, Accra, Ghana
- 47Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
- 48Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan
- 49Laboratory of Complex Trait Genomics, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo 108-8639, Japan
- 50Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan
- 51Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan
- 52National Institute for Health Research (NIHR) Biomedical Research Centre at Moorfields Eye Hospital National Health Service Foundation Trust & UCL Institute of Ophthalmology, London, UK
- 53UCL Institute of Ophthalmology, University College London, London, United Kingdom
- 54Cardiff Centre for Vision Sciences, College of Biomedical and Life Sciences, Maindy Road, Cardiff University, Cardiff, UK
- 55Harvard School of Public Health, Boston, MA, 02114, USA
- 56Channing Division of Network Medicine, Brigham and Women’s Hospital / Harvard Medical School, Boston, MA, 02114, USA
- 57The Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, Peoples Republic of China
- 58Centre for Vision Research, Department of Ophthalmology and Westmead Institute for Medical Research, University of Sydney, NSW 2145, Sydney, NSW, Australia
- 59Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland
- 60Analytical and Translational Genetics Unit (ATGU), Psychiatric & Neurodevelopmental Genetics Unit, Departments of Psychiatry and Neurology, Massachusetts General Hospital, Boston, MA, USA
- 61Broad Institute of MIT and Harvard, Cambridge, MA, USA
- 62Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA
- 63Department of Ophthalmology, Radboud University Medical Center, Nijmegen, the Netherlands
- 64Institute for Molecular and Clinical Ophthalmology, Basel, Switzerland
- 65Department of Medicine, Duke University, Durham, North Carolina
- 66Department of Ophthalmology, Duke University, Durham, North Carolina
- 67Singapore Eye Research Institute, Singapore; Duke-NUS Medical School, Signapore
- 68Division of Human Genetics, Genome Institute of Singapore, Singapore, Singapore
- 69Centre for Ophthalmology and Visual Science, University of Western Australia, Lions Eye Institute
- 70RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan
- 71Department of Ophthalmology, Flinders University, Flinders Medical Centre, Bedford Park, Australia
- ↵&Correspondence should be made to Puya Gharahkhani at Puya.Gharahkhani{at}qimrberghofer.edu.au.
↵* These authors contributed equally.