Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Spatial Coding in the Subiculum Requires Anterior Thalamic Inputs

Beth Frost, Matheus Cafalchio, Sean K Martin, Md Nurul Islam, John Aggleton, View ORCID ProfileShane O'Mara
doi: https://doi.org/10.1101/2020.01.31.928762
Beth Frost
Trinity College Dublin;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: frostb@tcd.ie
Matheus Cafalchio
Trinity College Dublin;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: cafalchm@tcd.ie
Sean K Martin
Trinity College Dublin;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: smartin5@tcd.ie
Md Nurul Islam
Trinity College Dublin;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: mnislam.raju@gmail.com
John Aggleton
Cardiff University;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: aggleton@cardiff.ac.uk
Shane O'Mara
Trinity College Dublin - the University of Dublin
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Shane O'Mara
  • For correspondence: smomara@tcd.ie
  • Abstract
  • Info/History
  • Metrics
  • Preview PDF
Loading

Abstract

Hippocampal function relies on the anterior thalamic nuclei, yet the reasons remain poorly understood. While anterior thalamic lesions disrupt parahippocampal spatial signalling, their impact on the subiculum is unknown, despite the importance of this area for hippocampal networks. We recorded subiculum cells in rats with either permanent (N-methyl-D-aspartic acid) or reversible (muscimol) anterior thalamic lesions. The diverse spatial signals normally found in the subiculum, including place cells, disappeared following permanent thalamic lesions and showed marked disruption during transient lesions. Meanwhile, permanent anterior thalamic lesions had no discernible impact on CA1 place fields. Thalamic lesions reduced spatial alternation performance (permanently or reversibly) to chance levels, while leaving a non-spatial recognition memory task unaffected. These findings, which help to explain why anterior thalamic damage is so deleterious for spatial memory, cast a new spotlight on the importance of subiculum function, and reveal its dependence on anterior thalamic signalling.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Back to top
PreviousNext
Posted February 02, 2020.
Download PDF
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Spatial Coding in the Subiculum Requires Anterior Thalamic Inputs
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
Share
Spatial Coding in the Subiculum Requires Anterior Thalamic Inputs
Beth Frost, Matheus Cafalchio, Sean K Martin, Md Nurul Islam, John Aggleton, Shane O'Mara
bioRxiv 2020.01.31.928762; doi: https://doi.org/10.1101/2020.01.31.928762
Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
Citation Tools
Spatial Coding in the Subiculum Requires Anterior Thalamic Inputs
Beth Frost, Matheus Cafalchio, Sean K Martin, Md Nurul Islam, John Aggleton, Shane O'Mara
bioRxiv 2020.01.31.928762; doi: https://doi.org/10.1101/2020.01.31.928762

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Neuroscience
Subject Areas
All Articles
  • Animal Behavior and Cognition (1641)
  • Biochemistry (2721)
  • Bioengineering (1902)
  • Bioinformatics (10202)
  • Biophysics (4174)
  • Cancer Biology (3202)
  • Cell Biology (4522)
  • Clinical Trials (135)
  • Developmental Biology (2831)
  • Ecology (4447)
  • Epidemiology (2041)
  • Evolutionary Biology (7213)
  • Genetics (5464)
  • Genomics (6795)
  • Immunology (2379)
  • Microbiology (7462)
  • Molecular Biology (2978)
  • Neuroscience (18529)
  • Paleontology (135)
  • Pathology (472)
  • Pharmacology and Toxicology (776)
  • Physiology (1147)
  • Plant Biology (2692)
  • Scientific Communication and Education (679)
  • Synthetic Biology (885)
  • Systems Biology (2840)
  • Zoology (465)