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The novel coronavirus 2019 (2019-nCoV) uses the SARS-coronavirus receptor ACE2 and the cellular protease TMPRSS2 for entry into target cells

View ORCID ProfileMarkus Hoffmann, Hannah Kleine-Weber, View ORCID ProfileNadine Krüger, View ORCID ProfileMarcel Müller, Christian Drosten, View ORCID ProfileStefan Pöhlmann
doi: https://doi.org/10.1101/2020.01.31.929042
Markus Hoffmann
1Infection Biology Unit, German Primate Center – Leibniz Institute for Primate Research, Göttingen, Germany
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  • For correspondence: mhoffmann@dpz.eu spoehlmann@dpz.eu
Hannah Kleine-Weber
1Infection Biology Unit, German Primate Center – Leibniz Institute for Primate Research, Göttingen, Germany
2Faculty of Biology and Psychology, University Göttingen, Göttingen, Germany
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Nadine Krüger
3Institute of Virology, University of Veterinary Medicine Hannover, Hannover, Germany
4Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine Hannover, Hannover, Germany
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Marcel Müller
5German Centre for Infection Research, associated partner Charité, Berlin, Germany
6Martsinovsky Institute of Medical Parasitology, Tropical and Vector Borne Diseases, Sechenov University, Moscow, Russia
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Christian Drosten
5German Centre for Infection Research, associated partner Charité, Berlin, Germany
6Martsinovsky Institute of Medical Parasitology, Tropical and Vector Borne Diseases, Sechenov University, Moscow, Russia
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Stefan Pöhlmann
1Infection Biology Unit, German Primate Center – Leibniz Institute for Primate Research, Göttingen, Germany
2Faculty of Biology and Psychology, University Göttingen, Göttingen, Germany
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  • For correspondence: mhoffmann@dpz.eu spoehlmann@dpz.eu
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Article Information

doi 
https://doi.org/10.1101/2020.01.31.929042
History 
  • January 31, 2020.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Markus Hoffmann1,*,†,
  2. Hannah Kleine-Weber1,2,†,
  3. Nadine Krüger3,4,
  4. Marcel Müller5,6,
  5. Christian Drosten5,6 and
  6. Stefan Pöhlmann1,2,*
  1. 1Infection Biology Unit, German Primate Center – Leibniz Institute for Primate Research, Göttingen, Germany
  2. 2Faculty of Biology and Psychology, University Göttingen, Göttingen, Germany
  3. 3Institute of Virology, University of Veterinary Medicine Hannover, Hannover, Germany
  4. 4Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine Hannover, Hannover, Germany
  5. 4Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Virology, Berlin, Germany
  6. 5German Centre for Infection Research, associated partner Charité, Berlin, Germany
  7. 6Martsinovsky Institute of Medical Parasitology, Tropical and Vector Borne Diseases, Sechenov University, Moscow, Russia
  1. ↵*Corresponding authors. E-mail: mhoffmann{at}dpz.eu (M.H.), spoehlmann{at}dpz.eu (S.P.)
  1. ↵† These authors contributed equally

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Posted January 31, 2020.
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The novel coronavirus 2019 (2019-nCoV) uses the SARS-coronavirus receptor ACE2 and the cellular protease TMPRSS2 for entry into target cells
Markus Hoffmann, Hannah Kleine-Weber, Nadine Krüger, Marcel Müller, Christian Drosten, Stefan Pöhlmann
bioRxiv 2020.01.31.929042; doi: https://doi.org/10.1101/2020.01.31.929042
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The novel coronavirus 2019 (2019-nCoV) uses the SARS-coronavirus receptor ACE2 and the cellular protease TMPRSS2 for entry into target cells
Markus Hoffmann, Hannah Kleine-Weber, Nadine Krüger, Marcel Müller, Christian Drosten, Stefan Pöhlmann
bioRxiv 2020.01.31.929042; doi: https://doi.org/10.1101/2020.01.31.929042

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