Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

A wireless, implantable optoelectrochemical probe for optogenetic stimulation and dopamine detection

View ORCID ProfileXing Sheng
doi: https://doi.org/10.1101/2020.02.02.926782
Xing Sheng
Tsinghua University
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Xing Sheng
  • For correspondence: xingsheng@tsinghua.edu.cn
  • Abstract
  • Info/History
  • Metrics
  • Preview PDF
Loading

Abstract

Physical and chemical technologies have been continuously progressing advances of neuroscience research. The development of research tools for closed-loop control and monitoring neural activities in behaving animals is highly desirable. In this paper, we introduce a wirelessly operated, miniaturized microprobe system for optical interrogation and neurochemical sensing in the deep brain. Via epitaxial liftoff and transfer printing, microscale light emitting diodes (micro-LEDs) as light sources, and poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) coated diamond films as electrochemical sensors are vertically assembled to form implantable optoelectrochemical probes, for real-time optogenetic stimulation and dopamine detection capabilities. A customized, lightweight circuit module is employed for untethered, remote signal control and data acquisition. Injected into the ventral tegmental area (VTA) of freely behaving mice, in vivo experiments clearly demonstrate the utilities of the multifunctional optoelectrochemical microprobe system for optogenetic interference of place preferences and detection of dopamine release. The presented options for material and device integrations provide a practical route to simultaneous optical control and electrochemical sensing of complex nervous systems.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
Back to top
PreviousNext
Posted February 02, 2020.
Download PDF
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
A wireless, implantable optoelectrochemical probe for optogenetic stimulation and dopamine detection
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
Share
A wireless, implantable optoelectrochemical probe for optogenetic stimulation and dopamine detection
Xing Sheng
bioRxiv 2020.02.02.926782; doi: https://doi.org/10.1101/2020.02.02.926782
Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
Citation Tools
A wireless, implantable optoelectrochemical probe for optogenetic stimulation and dopamine detection
Xing Sheng
bioRxiv 2020.02.02.926782; doi: https://doi.org/10.1101/2020.02.02.926782

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Bioengineering
Subject Areas
All Articles
  • Animal Behavior and Cognition (1641)
  • Biochemistry (2721)
  • Bioengineering (1902)
  • Bioinformatics (10201)
  • Biophysics (4174)
  • Cancer Biology (3202)
  • Cell Biology (4522)
  • Clinical Trials (135)
  • Developmental Biology (2831)
  • Ecology (4447)
  • Epidemiology (2041)
  • Evolutionary Biology (7213)
  • Genetics (5463)
  • Genomics (6793)
  • Immunology (2379)
  • Microbiology (7462)
  • Molecular Biology (2978)
  • Neuroscience (18529)
  • Paleontology (135)
  • Pathology (472)
  • Pharmacology and Toxicology (776)
  • Physiology (1147)
  • Plant Biology (2692)
  • Scientific Communication and Education (679)
  • Synthetic Biology (885)
  • Systems Biology (2840)
  • Zoology (465)