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Detection of hypermucoviscous Klebsiella pneumoniae sequence type 86 capsular type K2 in South America as an unexpected cause of a fatal outbreak in captivity marmosets

Juliana Guerra, Natalia Fernandes, Alessandra Santos, Joana Barrel, Bruno Petri, Liliane Milanelo, Monique Tiba-Casas, Alcina Liserre, Claudia Goncalves, Claudio Sacchi, Jose Catao-Dias, Carlos Henrique Camargo
doi: https://doi.org/10.1101/2020.02.02.930685
Juliana Guerra
Instituto Adolfo Lutz;
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  • For correspondence: jumariotti.vet@gmail.com
Natalia Fernandes
Instituto Adolfo Lutz, Universidade de Sao Paulo;
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  • For correspondence: nccafernandes@yahoo.com.br
Alessandra Santos
Instituto Adolfo Lutz, Universidade de Sao Paulo;
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  • For correspondence: alessandralmsantos@gmail.com
Joana Barrel
Instituto Adolfo Lutz;
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  • For correspondence: joana_souzap@hotmail.com
Bruno Petri
Parque Ecologico do Tiete;
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  • For correspondence: brunopetri_mv@yahoo.com.br
Liliane Milanelo
Parque Ecologico do Tiete;
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  • For correspondence: lmilanelo@yahoo.com.br
Monique Tiba-Casas
Instituto Adolfo Lutz;
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  • For correspondence: mrtiba@gmail.com
Alcina Liserre
Instituto Adolfo Lutz;
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  • For correspondence: alcinalis@ig.com.br
Claudia Goncalves
Instituto Adolfo Lutz;
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  • For correspondence: claudiaregina73@hotmail.com
Claudio Sacchi
Instituto Adolfo Lutz;
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  • For correspondence: ctsacchi@gmail.com
Jose Catao-Dias
Universidade de Sao Paulo
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  • For correspondence: zecatao@usp.br
Carlos Henrique Camargo
Instituto Adolfo Lutz;
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  • For correspondence: carlos.camargo@ial.sp.gov.br
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Abstract

After the sudden death of eleven captives marmosets in a rehabilitation center of wildlife in Sao Paulo, Brazil, histological and microbiological study was conducted. Liver, spleen, intestine, central nervous system, lung, thymus, stomach, testicle tissues were analyzed by light microscopy and microbial cultures were conducted. Environmental cultures were also performed. Prophylactic antimicrobial therapy, restricted access to marmosets' cages with dedicated staff, and additional sanitization of animals' fruits were implemented. Histological findings were compatible with hyperacute septicemia, and microbiological cultures and molecular tests identified the etiologic agent as hypermucoviscous sequence type 86 capsular type K2 K. pneumoniae for the first time in South America. Implementation of prompt containment measures led to successful control of this outbreak. Detection of a hypervirulent and zoonotic pathogen, such as hypermucoviscous K. pneumoniae ST86 K2, in an unexpected and human interface reservoir underscores its potential threat in public health settings.

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Posted February 02, 2020.
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Detection of hypermucoviscous Klebsiella pneumoniae sequence type 86 capsular type K2 in South America as an unexpected cause of a fatal outbreak in captivity marmosets
Juliana Guerra, Natalia Fernandes, Alessandra Santos, Joana Barrel, Bruno Petri, Liliane Milanelo, Monique Tiba-Casas, Alcina Liserre, Claudia Goncalves, Claudio Sacchi, Jose Catao-Dias, Carlos Henrique Camargo
bioRxiv 2020.02.02.930685; doi: https://doi.org/10.1101/2020.02.02.930685
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Detection of hypermucoviscous Klebsiella pneumoniae sequence type 86 capsular type K2 in South America as an unexpected cause of a fatal outbreak in captivity marmosets
Juliana Guerra, Natalia Fernandes, Alessandra Santos, Joana Barrel, Bruno Petri, Liliane Milanelo, Monique Tiba-Casas, Alcina Liserre, Claudia Goncalves, Claudio Sacchi, Jose Catao-Dias, Carlos Henrique Camargo
bioRxiv 2020.02.02.930685; doi: https://doi.org/10.1101/2020.02.02.930685

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