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Functional Importance of Second Heart Field-derived Cells During Thoracic Aortic Aneurysm Formation

View ORCID ProfileHisashi Sawada, Hideyuki Higashi, Rateri L Debra, View ORCID ProfileJeff Z Chen, View ORCID ProfileJessica J Moorleghen, Deborah A Howatt, View ORCID ProfileHong Shen Lu, Stephanie Morgan, View ORCID ProfileSasha A Singh, View ORCID ProfileMasanori Aikawa, View ORCID ProfileMark W Majesky, View ORCID ProfileAlan Daugherty
doi: https://doi.org/10.1101/2020.02.02.930917
Hisashi Sawada
University of Kentucky;
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  • For correspondence: hisashi.sawada@uky.edu
Hideyuki Higashi
Harvard Medical School;
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  • For correspondence: hide.11810@gmail.com
Rateri L Debra
University of Kentucky;
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  • For correspondence: debra.rateri@uky.edu
Jeff Z Chen
University of Kentucky;
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  • For correspondence: jeff.chen@uky.edu
Jessica J Moorleghen
University of Kentucky;
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  • For correspondence: jjmoorl@uky.edu
Deborah A Howatt
University of Kentucky;
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  • For correspondence: ddhowa2@email.uky.edu
Hong Shen Lu
University of Kentucky;
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  • For correspondence: hong.lu@uky.edu
Stephanie Morgan
Harvard Medical School;
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  • For correspondence: steff.morgan@gmail.com
Sasha A Singh
Harvard Medical School;
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  • For correspondence: sasingh@bwh.harvard.edu
Masanori Aikawa
Harvard Medical School;
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  • For correspondence: maikawa@bwh.harvard.edu
Mark W Majesky
University of Washington
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  • For correspondence: mwm84@uw.edu
Alan Daugherty
University of Kentucky;
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  • For correspondence: alan.daugherty@uky.edu
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Abstract

Embryonic origins of smooth muscle cells (SMCs) may contribute to regional specificity of thoracic aortic aneurysms. Here, we demonstrate that SMCs derived from the second heart field localized with angiotensin II-induced aortopathies. Proteomics analysis discerned potential roles of Lrp1 and TGF-β pathways, and genetic ablation of these pathways in second heart field-derived cells augmented aortopathies, indicating functional importance of this origin on aortic integrity.

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Posted February 02, 2020.
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Functional Importance of Second Heart Field-derived Cells During Thoracic Aortic Aneurysm Formation
Hisashi Sawada, Hideyuki Higashi, Rateri L Debra, Jeff Z Chen, Jessica J Moorleghen, Deborah A Howatt, Hong Shen Lu, Stephanie Morgan, Sasha A Singh, Masanori Aikawa, Mark W Majesky, Alan Daugherty
bioRxiv 2020.02.02.930917; doi: https://doi.org/10.1101/2020.02.02.930917
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Functional Importance of Second Heart Field-derived Cells During Thoracic Aortic Aneurysm Formation
Hisashi Sawada, Hideyuki Higashi, Rateri L Debra, Jeff Z Chen, Jessica J Moorleghen, Deborah A Howatt, Hong Shen Lu, Stephanie Morgan, Sasha A Singh, Masanori Aikawa, Mark W Majesky, Alan Daugherty
bioRxiv 2020.02.02.930917; doi: https://doi.org/10.1101/2020.02.02.930917

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