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Ancient MAPK ERK7 is regulated by an unusual inhibitory scaffold required for Toxoplasma apical complex biogenesis

View ORCID ProfilePeter S. Back, William J. O’Shaughnessy, Andy S. Moon, Pravin S. Dewangan, Xiaoyu Hu, Jihui Sha, James A. Wohlschlegel, View ORCID ProfilePeter J. Bradley, View ORCID ProfileMichael L. Reese
doi: https://doi.org/10.1101/2020.02.02.931089
Peter S. Back
1Molecular Biology Institute, University of California, Los Angeles, Los Angeles, California
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  • ORCID record for Peter S. Back
William J. O’Shaughnessy
2Department of Pharmacology, University of Texas, Southwestern Medical Center, Dallas, TX USA
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Andy S. Moon
3Department of Molecular Microbiology and Immunology, University of California, Los Angeles, CA USA
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Pravin S. Dewangan
2Department of Pharmacology, University of Texas, Southwestern Medical Center, Dallas, TX USA
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Xiaoyu Hu
2Department of Pharmacology, University of Texas, Southwestern Medical Center, Dallas, TX USA
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Jihui Sha
4Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA
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James A. Wohlschlegel
4Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA
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Peter J. Bradley
1Molecular Biology Institute, University of California, Los Angeles, Los Angeles, California
3Department of Molecular Microbiology and Immunology, University of California, Los Angeles, CA USA
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  • For correspondence: michael.reese@utsouthwestern.edu pbradley@ucla.edu
Michael L. Reese
2Department of Pharmacology, University of Texas, Southwestern Medical Center, Dallas, TX USA
5Department of Biochemistry, University of Texas, Southwestern Medical Center, Dallas, TX USA
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  • ORCID record for Michael L. Reese
  • For correspondence: michael.reese@utsouthwestern.edu pbradley@ucla.edu
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Article Information

doi 
https://doi.org/10.1101/2020.02.02.931089
History 
  • March 20, 2020.

Article Versions

  • Version 1 (February 2, 2020 - 15:42).
  • You are viewing Version 2, the most recent version of this article.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.

Author Information

  1. Peter S. Back1,†,
  2. William J. O’Shaughnessy2,†,
  3. Andy S. Moon3,
  4. Pravin S. Dewangan2,
  5. Xiaoyu Hu2,
  6. Jihui Sha4,
  7. James A. Wohlschlegel4,
  8. Peter J. Bradley1,3,* and
  9. Michael L. Reese2,5,*
  1. 1Molecular Biology Institute, University of California, Los Angeles, Los Angeles, California
  2. 2Department of Pharmacology, University of Texas, Southwestern Medical Center, Dallas, TX USA
  3. 3Department of Molecular Microbiology and Immunology, University of California, Los Angeles, CA USA
  4. 4Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA
  5. 5Department of Biochemistry, University of Texas, Southwestern Medical Center, Dallas, TX USA
  1. ↵*Address correspondence to Michael L. Reese, michael.reese{at}utsouthwestern.edu or to Peter Bradley, pbradley{at}ucla.edu
  1. ↵† P.S.B. and W.J.O. contributed equally to this work.

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Posted March 20, 2020.
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Ancient MAPK ERK7 is regulated by an unusual inhibitory scaffold required for Toxoplasma apical complex biogenesis
Peter S. Back, William J. O’Shaughnessy, Andy S. Moon, Pravin S. Dewangan, Xiaoyu Hu, Jihui Sha, James A. Wohlschlegel, Peter J. Bradley, Michael L. Reese
bioRxiv 2020.02.02.931089; doi: https://doi.org/10.1101/2020.02.02.931089
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Ancient MAPK ERK7 is regulated by an unusual inhibitory scaffold required for Toxoplasma apical complex biogenesis
Peter S. Back, William J. O’Shaughnessy, Andy S. Moon, Pravin S. Dewangan, Xiaoyu Hu, Jihui Sha, James A. Wohlschlegel, Peter J. Bradley, Michael L. Reese
bioRxiv 2020.02.02.931089; doi: https://doi.org/10.1101/2020.02.02.931089

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