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Cross-platform genetic discovery of small molecule products of metabolism and application to clinical outcomes
Luca A. Lotta, Maik Pietzner, Isobel D. Stewart, Laura B.L. Wittemans, Chen Li, Roberto Bonelli, Johannes Raffler, Emma K. Biggs, Clare Oliver-Williams, Victoria P.W. Auyeung, Jian’an Luan, Eleanor Wheeler, Ellie Paige, Praveen Surendran, Gregory A. Michelotti, Robert A. Scott, Stephen Burgess, Verena Zuber, Eleanor Sanderson, Albert Koulman, Fumiaki Imamura, Nita G. Forouhi, Kay-Tee Khaw, MacTel Consortium, Julian L. Griffin, Angela M. Wood, View ORCID ProfileGabi Kastenmüller, John Danesh, Adam S. Butterworth, Fiona M. Gribble, Frank Reimann, View ORCID ProfileMelanie Bahlo, Eric Fauman, Nicholas J. Wareham, Claudia Langenberg
doi: https://doi.org/10.1101/2020.02.03.932541
Luca A. Lotta
1MRC Epidemiology Unit, University of Cambridge, Cambridge, UK
Maik Pietzner
1MRC Epidemiology Unit, University of Cambridge, Cambridge, UK
Isobel D. Stewart
1MRC Epidemiology Unit, University of Cambridge, Cambridge, UK
Laura B.L. Wittemans
1MRC Epidemiology Unit, University of Cambridge, Cambridge, UK
2The Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford
Chen Li
1MRC Epidemiology Unit, University of Cambridge, Cambridge, UK
Roberto Bonelli
3Population Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
4Department of Medical Biology, The University of Melbourne, Parkville, Australia
Johannes Raffler
5Institute of Computational Biology, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany
Emma K. Biggs
6Metabolic Research Laboratories, University of Cambridge, Cambridge, United Kingdom
Clare Oliver-Williams
7British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
8Homerton College, University of Cambridge, Cambridge, UK
Victoria P.W. Auyeung
1MRC Epidemiology Unit, University of Cambridge, Cambridge, UK
Jian’an Luan
1MRC Epidemiology Unit, University of Cambridge, Cambridge, UK
Eleanor Wheeler
1MRC Epidemiology Unit, University of Cambridge, Cambridge, UK
Ellie Paige
9National Centre for Epidemiology and Population Health, The Australian National University, Canberra, Australia
Praveen Surendran
7British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
10British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK
11Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK
12Rutherford Fund Fellow, Department of Public Health and Primary Care, University of Cambridge, UK
Gregory A. Michelotti
13Metabolon Inc, Durham, North Carolina USA
Robert A. Scott
1MRC Epidemiology Unit, University of Cambridge, Cambridge, UK
Stephen Burgess
14MRC Biostatistics Unit, University of Cambridge, Cambridge, United Kingdom
15Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
Verena Zuber
14MRC Biostatistics Unit, University of Cambridge, Cambridge, United Kingdom
16Department of Epidemiology and Biostatistics, Imperial College London, UK
Eleanor Sanderson
17MRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, UK
Albert Koulman
1MRC Epidemiology Unit, University of Cambridge, Cambridge, UK
5Institute of Computational Biology, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany
18NIHR BRC Nutritional Biomarker Laboratory, University of Cambridge, UK
Fumiaki Imamura
1MRC Epidemiology Unit, University of Cambridge, Cambridge, UK
Nita G. Forouhi
1MRC Epidemiology Unit, University of Cambridge, Cambridge, UK
Kay-Tee Khaw
15Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
Julian L. Griffin
19Biomolecular Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, UK
Angela M. Wood
7British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
10British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK
11Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK
20National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK
21The Alan Turing Institute, London, UK
Gabi Kastenmüller
5Institute of Computational Biology, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany
John Danesh
7British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
10British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK
11Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK
20National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK
22National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, UK
23Department of Human Genetics, Wellcome Sanger Institute, Hinxton, UK
Adam S. Butterworth
7British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
10British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK
11Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK
20National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK
22National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, UK
23Department of Human Genetics, Wellcome Sanger Institute, Hinxton, UK
Fiona M. Gribble
6Metabolic Research Laboratories, University of Cambridge, Cambridge, United Kingdom
Frank Reimann
6Metabolic Research Laboratories, University of Cambridge, Cambridge, United Kingdom
Melanie Bahlo
3Population Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
4Department of Medical Biology, The University of Melbourne, Parkville, Australia
Eric Fauman
24Internal Medicine Research Unit, Pfizer Worldwide Research, Cambridge, MA 02142, USA
Nicholas J. Wareham
1MRC Epidemiology Unit, University of Cambridge, Cambridge, UK
Claudia Langenberg
1MRC Epidemiology Unit, University of Cambridge, Cambridge, UK
11Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK
Article usage
Posted July 03, 2020.
Cross-platform genetic discovery of small molecule products of metabolism and application to clinical outcomes
Luca A. Lotta, Maik Pietzner, Isobel D. Stewart, Laura B.L. Wittemans, Chen Li, Roberto Bonelli, Johannes Raffler, Emma K. Biggs, Clare Oliver-Williams, Victoria P.W. Auyeung, Jian’an Luan, Eleanor Wheeler, Ellie Paige, Praveen Surendran, Gregory A. Michelotti, Robert A. Scott, Stephen Burgess, Verena Zuber, Eleanor Sanderson, Albert Koulman, Fumiaki Imamura, Nita G. Forouhi, Kay-Tee Khaw, MacTel Consortium, Julian L. Griffin, Angela M. Wood, Gabi Kastenmüller, John Danesh, Adam S. Butterworth, Fiona M. Gribble, Frank Reimann, Melanie Bahlo, Eric Fauman, Nicholas J. Wareham, Claudia Langenberg
bioRxiv 2020.02.03.932541; doi: https://doi.org/10.1101/2020.02.03.932541
Cross-platform genetic discovery of small molecule products of metabolism and application to clinical outcomes
Luca A. Lotta, Maik Pietzner, Isobel D. Stewart, Laura B.L. Wittemans, Chen Li, Roberto Bonelli, Johannes Raffler, Emma K. Biggs, Clare Oliver-Williams, Victoria P.W. Auyeung, Jian’an Luan, Eleanor Wheeler, Ellie Paige, Praveen Surendran, Gregory A. Michelotti, Robert A. Scott, Stephen Burgess, Verena Zuber, Eleanor Sanderson, Albert Koulman, Fumiaki Imamura, Nita G. Forouhi, Kay-Tee Khaw, MacTel Consortium, Julian L. Griffin, Angela M. Wood, Gabi Kastenmüller, John Danesh, Adam S. Butterworth, Fiona M. Gribble, Frank Reimann, Melanie Bahlo, Eric Fauman, Nicholas J. Wareham, Claudia Langenberg
bioRxiv 2020.02.03.932541; doi: https://doi.org/10.1101/2020.02.03.932541
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