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The Essential Facts of Wuhan Novel Coronavirus Outbreak in China and Epitope-based Vaccine Designing against 2019-nCoV

Bishajit Sarkar, Md. Asad Ullah, Fatema Tuz Johora, Masuma Afrin Taniya, Yusha Araf
doi: https://doi.org/10.1101/2020.02.05.935072
Bishajit Sarkar
1Department of Biotechnology and Genetic Engineering, Faculty of Biological Sciences, Jahangirnagar University, Dhaka, Bangladesh
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  • For correspondence: sarkarbishajit@gmail.com
Md. Asad Ullah
1Department of Biotechnology and Genetic Engineering, Faculty of Biological Sciences, Jahangirnagar University, Dhaka, Bangladesh
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Fatema Tuz Johora
1Department of Biotechnology and Genetic Engineering, Faculty of Biological Sciences, Jahangirnagar University, Dhaka, Bangladesh
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Masuma Afrin Taniya
2Department of Microbiology, School of Life Sciences, Independent University, Bangladesh, Dhaka, Bangladesh
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Yusha Araf
3Department of Genetic Engineering and Biotechnology, Faculty of Life Sciences, Shahjalal University of Science and Technology, Sylhet, Bangladesh
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Abstract

Wuhan Novel Coronavirus (2019-nCoV) outbreak has become global pandemic which has raised the concern of scientific community to deign and discover a definitive cure against this deadly virus which has caused deaths of numerous infected people upon infection and spreading. To date, there is no antiviral therapy or vaccine is available which can effectively combat the infection caused by this virus. This study was conducted to design possible epitope-based subunit vaccines against the 2019-nCoV using the approaches of reverse vaccinology and immunoinformatics. Upon continual computational experimentation three possible vaccine constructs were designed and one vaccine construct was selected as the best vaccine based on molecular docking study which is supposed to effectively act against the Wuhan Novel Coronavirus. Later, molecular dynamics simulation and in silico codon adaptation experiments were carried out in order to check biological stability and find effective mass production strategy of the selected vaccine. Hopefully, this study will contribute to uphold the present efforts of the researches to secure a definitive treatment against this nasty virus.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted February 11, 2020.
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The Essential Facts of Wuhan Novel Coronavirus Outbreak in China and Epitope-based Vaccine Designing against 2019-nCoV
Bishajit Sarkar, Md. Asad Ullah, Fatema Tuz Johora, Masuma Afrin Taniya, Yusha Araf
bioRxiv 2020.02.05.935072; doi: https://doi.org/10.1101/2020.02.05.935072
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The Essential Facts of Wuhan Novel Coronavirus Outbreak in China and Epitope-based Vaccine Designing against 2019-nCoV
Bishajit Sarkar, Md. Asad Ullah, Fatema Tuz Johora, Masuma Afrin Taniya, Yusha Araf
bioRxiv 2020.02.05.935072; doi: https://doi.org/10.1101/2020.02.05.935072

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