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Cortical network mechanisms of response inhibition

Michael Schaum, Edoardo Pinzuti, Alexandra Sebastian, Klaus Lieb, Pascal Fries, Arian Mobascher, Patrick Jung, Michael Wibral, Oliver Tüscher
doi: https://doi.org/10.1101/2020.02.09.940841
Michael Schaum
1Leibniz Institute for Resilience Research, 55122 Mainz, Germany
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  • For correspondence: Michael.Schaum@lir-mainz.de
Edoardo Pinzuti
1Leibniz Institute for Resilience Research, 55122 Mainz, Germany
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Alexandra Sebastian
2Department of Psychiatry and Psychotherapy, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, Germany
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Klaus Lieb
1Leibniz Institute for Resilience Research, 55122 Mainz, Germany
2Department of Psychiatry and Psychotherapy, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, Germany
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Pascal Fries
3Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, 60528 Frankfurt, Germany
5Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, 6525 EN Nijmegen, Netherlands
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Arian Mobascher
2Department of Psychiatry and Psychotherapy, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, Germany
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Patrick Jung
2Department of Psychiatry and Psychotherapy, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, Germany
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Michael Wibral
4Campus Institute for Dynamics of Biological Networks, Georg-August University, 37077 Göttingen, Germany
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Oliver Tüscher
1Leibniz Institute for Resilience Research, 55122 Mainz, Germany
2Department of Psychiatry and Psychotherapy, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, Germany
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Summary

Both the right inferior frontal gyrus (rIFG) and the pre-supplementary motor area (pre-SMA) are crucial for successful response inhibition. However, the particular functional roles of those two regions have been controversially debated for more than a decade now. It is unclear whether the rIFG directly initiates stopping or serves an attentional function, whereas the stopping is triggered by the pre-SMA. The current multimodal MEG/fMRI study sought to clarify the role and temporal activation order of both regions in response inhibition using a selective stopping task. This task dissociates inhibitory from attentional processes. Our results reliably reveal a temporal precedence of rIFG over pre-SMA. Moreover, connectivity during response inhibition is directed from rIFG to pre-SMA and predicts stopping performance. Response inhibition is implemented via beta-band oscillations. Our findings support the hypothesis that response inhibition is initiated by the rIFG as a form of attention-independent top-down control.

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Posted February 10, 2020.
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Cortical network mechanisms of response inhibition
Michael Schaum, Edoardo Pinzuti, Alexandra Sebastian, Klaus Lieb, Pascal Fries, Arian Mobascher, Patrick Jung, Michael Wibral, Oliver Tüscher
bioRxiv 2020.02.09.940841; doi: https://doi.org/10.1101/2020.02.09.940841
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Cortical network mechanisms of response inhibition
Michael Schaum, Edoardo Pinzuti, Alexandra Sebastian, Klaus Lieb, Pascal Fries, Arian Mobascher, Patrick Jung, Michael Wibral, Oliver Tüscher
bioRxiv 2020.02.09.940841; doi: https://doi.org/10.1101/2020.02.09.940841

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