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Explosive sensing with insect-based biorobots

Debajit Saha, Darshit Mehta, Ege Atlan, Rishabh Chandak, Mike Traner, Ray Lo, Prashant Gupta, Srikanth Singamaneni, Shantanu Chakrabartty, Barani Raman
doi: https://doi.org/10.1101/2020.02.10.940866
Debajit Saha
1Department of Biomedical Engineering, Washington University in St. Louis
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Darshit Mehta
1Department of Biomedical Engineering, Washington University in St. Louis
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Ege Atlan
1Department of Biomedical Engineering, Washington University in St. Louis
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Rishabh Chandak
1Department of Biomedical Engineering, Washington University in St. Louis
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Mike Traner
1Department of Biomedical Engineering, Washington University in St. Louis
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Ray Lo
1Department of Biomedical Engineering, Washington University in St. Louis
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Prashant Gupta
3Department of Mechanical Engineering and Material Science, Washington University in St. Louis
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Srikanth Singamaneni
3Department of Mechanical Engineering and Material Science, Washington University in St. Louis
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Shantanu Chakrabartty
1Department of Biomedical Engineering, Washington University in St. Louis
2Department of Electrical and Systems Engineering, Washington University in St. Louis
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Barani Raman
1Department of Biomedical Engineering, Washington University in St. Louis
2Department of Electrical and Systems Engineering, Washington University in St. Louis
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  • For correspondence: barani@wustl.edu
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ABSTRACT

Stand-off chemical sensing is an important capability with applications in several domains including homeland security. Engineered devices for this task, popularly referred to as electronic noses, have limited capacity compared to the broad-spectrum abilities of the biological olfactory system. Therefore, we propose a hybrid bio-electronic solution that directly takes advantage of the rich repertoire of olfactory sensors and sophisticated neural computational framework available in an insect olfactory system. We show that select subsets of neurons in the locust (Schistocerca americana) brain were activated upon exposure to various explosive chemical species (such as DNT and TNT). Responses from an ensemble of neurons provided a unique, multivariate fingerprint that allowed discrimination of explosive vapors from non-explosive chemical species and from each other. Notably, target chemical recognition could be achieved within a few hundred milliseconds of exposure. Finally, we developed a minimally-invasive surgical approach and mobile multi-unit electrophysiological recording system to tap into the neural signals in a locust brain and realize a biorobotic explosive sensing system. In sum, our study provides the first demonstration of how biological olfactory systems (sensors and computations) can be hijacked to develop a cyborg chemical sensing approach.

SUMMARY We demonstrate a bio-robotic chemical sensing approach where signals from an insect brain are directly utilized to detect and distinguish various explosive chemical vapors.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted February 11, 2020.
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Explosive sensing with insect-based biorobots
Debajit Saha, Darshit Mehta, Ege Atlan, Rishabh Chandak, Mike Traner, Ray Lo, Prashant Gupta, Srikanth Singamaneni, Shantanu Chakrabartty, Barani Raman
bioRxiv 2020.02.10.940866; doi: https://doi.org/10.1101/2020.02.10.940866
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Explosive sensing with insect-based biorobots
Debajit Saha, Darshit Mehta, Ege Atlan, Rishabh Chandak, Mike Traner, Ray Lo, Prashant Gupta, Srikanth Singamaneni, Shantanu Chakrabartty, Barani Raman
bioRxiv 2020.02.10.940866; doi: https://doi.org/10.1101/2020.02.10.940866

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