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Escargot is involved in labial and antennal imaginal disc development through two different developmental pathways

View ORCID ProfileFernando Rosales-Bravo, View ORCID ProfileIván Sánchez-Díaz, View ORCID ProfileEnrique Reynaud, View ORCID ProfileVerónica Narváez-Padilla
doi: https://doi.org/10.1101/2020.02.10.942862
Fernando Rosales-Bravo
1Centro de Investigación en Dinámica Celular, UAEM. Av. Universidad 1001, Chamilpa, 62209 Cuernavaca, Morelos, México
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  • ORCID record for Fernando Rosales-Bravo
Iván Sánchez-Díaz
2Instituto de Biotecnología, UNAM. Av. Universidad 2001, Chamilpa, 62210 Cuernavaca, Morelos, México
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Enrique Reynaud
2Instituto de Biotecnología, UNAM. Av. Universidad 2001, Chamilpa, 62210 Cuernavaca, Morelos, México
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Verónica Narváez-Padilla
1Centro de Investigación en Dinámica Celular, UAEM. Av. Universidad 1001, Chamilpa, 62209 Cuernavaca, Morelos, México
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  • For correspondence: vnarvaez@uaem.mx
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Abstract

In insects, imaginal discs form the adult structures. Imaginal discs are formed by two epithelial layers, the lower disc proper columnar epithelium and the upper peripodial squamous epithelium (also known as peripodial membrane). During morphogenesis and metamorphosis there is a complex crosstalk between these two epithelia that defines the final size and form of the adult organs. In this work we found that in the antennal disc, the dosage of the transcriptional factor Escargot (Esg) regulates the extension of the peripodial epithelium. A reduction in Esg expands the peripodial domain at the expense of the antennal disc proper causing a distortion of the anteroposterior compartments resulting in malformations or duplications of antennae and maxillary palps. In the labial disc, a different morphogenetic pathway controls its development, and loss of esg produces a complete loss of the proboscis through a pathway that involves dpp.

Summary statement The gene escargot regulates proboscis, maxillary palps and antennae development in Drosophila melanogaster through two different developmental pathways: one involving cell adhesion protein DE-cadherin and another through the signaling molecule decapentaplegic.

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Posted February 11, 2020.
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Escargot is involved in labial and antennal imaginal disc development through two different developmental pathways
Fernando Rosales-Bravo, Iván Sánchez-Díaz, Enrique Reynaud, Verónica Narváez-Padilla
bioRxiv 2020.02.10.942862; doi: https://doi.org/10.1101/2020.02.10.942862
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Escargot is involved in labial and antennal imaginal disc development through two different developmental pathways
Fernando Rosales-Bravo, Iván Sánchez-Díaz, Enrique Reynaud, Verónica Narváez-Padilla
bioRxiv 2020.02.10.942862; doi: https://doi.org/10.1101/2020.02.10.942862

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