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Small-molecule inhibition of Lats kinases promotes Yap-dependent proliferation in postmitotic mammalian tissues
Nathaniel Kastan, Ksenia Gnedeva, Theresa Alisch, Aleksandra A. Petelski, David J. Huggins, Jeanne Chiaravalli, Alla Aharanov, Avraham Shakked, Eldad Tzahor, Aaron Nagiel, Neil Segil, View ORCID ProfileA. J. Hudspeth
doi: https://doi.org/10.1101/2020.02.11.944157
Nathaniel Kastan
aHoward Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, New York, NY 10065, USA
Ksenia Gnedeva
aHoward Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, New York, NY 10065, USA
bEli and Edythe Broad CIRM Center for Regenerative Medicine and Stem Cell Research and Tina and Rick Caruso Department Otolaryngology-Head and Neck Surgery, University of Southern California, Los Angles, CA 90033, USA
Theresa Alisch
aHoward Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, New York, NY 10065, USA
Aleksandra A. Petelski
aHoward Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, New York, NY 10065, USA
David J. Huggins
cTri-Institutional Therapeutics Discovery Institute, New York, NY 10021, USA; Department of Physiology and Biophysics, Weill Cornell Medical College of Cornell University, New York, NY 10065, USA
Jeanne Chiaravalli
dHigh-Throughput Screening Resource Center, The Rockefeller University, New York, NY 10065, USA
Alla Aharanov
eDepartment of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 7610001, Israel
Avraham Shakked
eDepartment of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 7610001, Israel
Eldad Tzahor
eDepartment of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 7610001, Israel
Aaron Nagiel
fVision Center, Department of Surgery, Children’s Hospital Los Angeles, Los Angeles, CA, USA; Saban Research Institute, Children’s Hospital Los Angeles, Los Angeles, CA, USA; USC Roski Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
Neil Segil
bEli and Edythe Broad CIRM Center for Regenerative Medicine and Stem Cell Research and Tina and Rick Caruso Department Otolaryngology-Head and Neck Surgery, University of Southern California, Los Angles, CA 90033, USA
A. J. Hudspeth
aHoward Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, New York, NY 10065, USA
Article usage
Posted February 12, 2020.
Small-molecule inhibition of Lats kinases promotes Yap-dependent proliferation in postmitotic mammalian tissues
Nathaniel Kastan, Ksenia Gnedeva, Theresa Alisch, Aleksandra A. Petelski, David J. Huggins, Jeanne Chiaravalli, Alla Aharanov, Avraham Shakked, Eldad Tzahor, Aaron Nagiel, Neil Segil, A. J. Hudspeth
bioRxiv 2020.02.11.944157; doi: https://doi.org/10.1101/2020.02.11.944157
Small-molecule inhibition of Lats kinases promotes Yap-dependent proliferation in postmitotic mammalian tissues
Nathaniel Kastan, Ksenia Gnedeva, Theresa Alisch, Aleksandra A. Petelski, David J. Huggins, Jeanne Chiaravalli, Alla Aharanov, Avraham Shakked, Eldad Tzahor, Aaron Nagiel, Neil Segil, A. J. Hudspeth
bioRxiv 2020.02.11.944157; doi: https://doi.org/10.1101/2020.02.11.944157
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