Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Longitudinal analysis of naturally acquired antibodies to PfEMP1 CIDR domain variants and their association with malaria protection

Nyamekye Obeng-Adjei, View ORCID ProfileDaniel B. Larremore, Louise Turner, Aissata Ongoiba, Shanping Li, View ORCID ProfileSafiatou Doumbo, Takele B. Yazew, View ORCID ProfileKassoum Kayentao, Louis H. Miller, Boubacar Traore, Susan K. Pierce, View ORCID ProfileCaroline O. Buckee, View ORCID ProfileThomas Lavstsen, View ORCID ProfilePeter D. Crompton, View ORCID ProfileTuan M. Tran
doi: https://doi.org/10.1101/2020.02.11.944330
Nyamekye Obeng-Adjei
1Malaria Infection Biology and Immunity Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA
2Innate Immunity Research Unit, GlaxoSmithKline, Collegeville, Pennsylvania, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Daniel B. Larremore
3Department of Computer Science, University of Colorado Boulder, Boulder, Colorado, USA
4BioFrontiers Institute, University of Colorado Boulder, Boulder, Colorado, 80303, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Daniel B. Larremore
Louise Turner
5Centre for Medical Parasitology, Department of Immunology & Microbiology, University of Copenhagen and Department of Infectious Diseases, Rigshospitalet, 1017 Copenhagen, Denmark
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Aissata Ongoiba
6Mali International Center of Excellence in Research, University of Sciences, Technique and Technology of Bamako, Bamako, Mali
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Shanping Li
1Malaria Infection Biology and Immunity Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Safiatou Doumbo
6Mali International Center of Excellence in Research, University of Sciences, Technique and Technology of Bamako, Bamako, Mali
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Safiatou Doumbo
Takele B. Yazew
7Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kassoum Kayentao
6Mali International Center of Excellence in Research, University of Sciences, Technique and Technology of Bamako, Bamako, Mali
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Kassoum Kayentao
Louis H. Miller
8Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Boubacar Traore
6Mali International Center of Excellence in Research, University of Sciences, Technique and Technology of Bamako, Bamako, Mali
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Susan K. Pierce
7Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Caroline O. Buckee
9Center for Communicable Disease Dynamics, Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Caroline O. Buckee
Thomas Lavstsen
5Centre for Medical Parasitology, Department of Immunology & Microbiology, University of Copenhagen and Department of Infectious Diseases, Rigshospitalet, 1017 Copenhagen, Denmark
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Thomas Lavstsen
Peter D. Crompton
1Malaria Infection Biology and Immunity Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Peter D. Crompton
Tuan M. Tran
1Malaria Infection Biology and Immunity Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA
10Division of Infectious Diseases, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
11Ryan White Center for Pediatric Infectious Disease and Global Health, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Tuan M. Tran
  • For correspondence: tuantran@iu.edu
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Supplementary material
  • Preview PDF
Loading

ABSTRACT

Malaria pathogenicity is determined, in part, by the adherence of Plasmodium falciparum infected erythrocytes to the microvasculature mediated via specific interactions between PfEMP1 variant domains to host endothelial receptors. Naturally acquired antibodies against specific PfEMP1 variants can play an important role in clinical protection against malaria. We evaluated IgG responses against a repertoire of PfEMP1 CIDR domain variants to determine the rate and order of variant-specific antibody acquisition and their association with protection against febrile malaria in a prospective cohort study conducted in an area of intense, seasonal malaria transmission. Using longitudinal data, we found that IgG to the pathogenic domain variants CIDRα1.7 and CIDRα1.8 were acquired the earliest. Furthermore, IgG to CIDRγ3 was associated with reduced prospective risk of febrile malaria and recurrent malaria episodes. Future studies will need to validate these findings in other transmission settings and determine the functional activity of these naturally acquired CIDR variant-specific antibodies.

Footnotes

  • Minor revisions that including formatting, grammar, sentence structure, and higher resolution figures.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Back to top
PreviousNext
Posted February 16, 2020.
Download PDF

Supplementary Material

Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Longitudinal analysis of naturally acquired antibodies to PfEMP1 CIDR domain variants and their association with malaria protection
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Longitudinal analysis of naturally acquired antibodies to PfEMP1 CIDR domain variants and their association with malaria protection
Nyamekye Obeng-Adjei, Daniel B. Larremore, Louise Turner, Aissata Ongoiba, Shanping Li, Safiatou Doumbo, Takele B. Yazew, Kassoum Kayentao, Louis H. Miller, Boubacar Traore, Susan K. Pierce, Caroline O. Buckee, Thomas Lavstsen, Peter D. Crompton, Tuan M. Tran
bioRxiv 2020.02.11.944330; doi: https://doi.org/10.1101/2020.02.11.944330
Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
Citation Tools
Longitudinal analysis of naturally acquired antibodies to PfEMP1 CIDR domain variants and their association with malaria protection
Nyamekye Obeng-Adjei, Daniel B. Larremore, Louise Turner, Aissata Ongoiba, Shanping Li, Safiatou Doumbo, Takele B. Yazew, Kassoum Kayentao, Louis H. Miller, Boubacar Traore, Susan K. Pierce, Caroline O. Buckee, Thomas Lavstsen, Peter D. Crompton, Tuan M. Tran
bioRxiv 2020.02.11.944330; doi: https://doi.org/10.1101/2020.02.11.944330

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Immunology
Subject Areas
All Articles
  • Animal Behavior and Cognition (2518)
  • Biochemistry (4968)
  • Bioengineering (3473)
  • Bioinformatics (15185)
  • Biophysics (6886)
  • Cancer Biology (5380)
  • Cell Biology (7718)
  • Clinical Trials (138)
  • Developmental Biology (4521)
  • Ecology (7135)
  • Epidemiology (2059)
  • Evolutionary Biology (10211)
  • Genetics (7504)
  • Genomics (9774)
  • Immunology (4826)
  • Microbiology (13186)
  • Molecular Biology (5130)
  • Neuroscience (29370)
  • Paleontology (203)
  • Pathology (836)
  • Pharmacology and Toxicology (1461)
  • Physiology (2131)
  • Plant Biology (4738)
  • Scientific Communication and Education (1008)
  • Synthetic Biology (1337)
  • Systems Biology (4003)
  • Zoology (768)