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A cerebellar internal model calibrates a feedback controller involved in sensorimotor control

Daniil A. Markov, Luigi Petrucco, View ORCID ProfileAndreas M. Kist, View ORCID ProfileRuben Portugues
doi: https://doi.org/10.1101/2020.02.12.945956
Daniil A. Markov
1Sensorimotor Control Research Group, Max Planck Institute of Neurobiology, Martinsried, 82152, Germany
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Luigi Petrucco
1Sensorimotor Control Research Group, Max Planck Institute of Neurobiology, Martinsried, 82152, Germany
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Andreas M. Kist
1Sensorimotor Control Research Group, Max Planck Institute of Neurobiology, Martinsried, 82152, Germany
2Division of Phoniatrics and Pediatric Audiology, Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, 91054, Germany
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Ruben Portugues
1Sensorimotor Control Research Group, Max Planck Institute of Neurobiology, Martinsried, 82152, Germany
3Institute of Neuroscience, Technical University of Munich, Munich, Germany
4Munich Cluster for Systems Neurology (SyNergy), Munich, Germany
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  • ORCID record for Ruben Portugues
  • For correspondence: ruben.portugues@tum.de
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Abstract

Animals must adapt their behavior to survive in a changing environment. Behavioral adaptations can be evoked by two mechanisms: feedback control and internal-model-based control. Feedback controllers can maintain the sensory state of the animal at a desired level under different environmental conditions. In turn, internal models learn the relationship between behavior and resulting sensory consequences in order to modify the behavior when this relationship changes. Here, we present multiple perturbations in visual feedback to larval zebrafish performing the optomotor response and show that they react to these perturbations through a feedback control mechanism. In contrast, if a perturbation is long-lasting, fish adapt their behavior by updating a cerebellum-dependent internal model. We use modelling and functional imaging to show that neuronal requirements for these mechanisms are met in the larval zebrafish brain. Our results illustrate the role of the cerebellum in encoding internal models and how these can calibrate neuronal circuits involved in reactive behaviors depending on the interactions between animal and environment.

Highlights

  • Behavioral reactions to unexpected changes in visual feedback are implemented by a feedback control mechanism

  • A long-lasting change in visual feedback updates the state of the neuronal controller

  • The cerebellar internal model mediates this recalibration

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted September 14, 2020.
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A cerebellar internal model calibrates a feedback controller involved in sensorimotor control
Daniil A. Markov, Luigi Petrucco, Andreas M. Kist, Ruben Portugues
bioRxiv 2020.02.12.945956; doi: https://doi.org/10.1101/2020.02.12.945956
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A cerebellar internal model calibrates a feedback controller involved in sensorimotor control
Daniil A. Markov, Luigi Petrucco, Andreas M. Kist, Ruben Portugues
bioRxiv 2020.02.12.945956; doi: https://doi.org/10.1101/2020.02.12.945956

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