Abstract
Most existing multi-compartment, mammalian neuron models are built from rodent data. However, our increasing knowledge of differences between human and rodent neurons suggests that, to understand the cellular basis of human brain function, we should build models from human data. Here, we present the first full spiking, multi-compartment model of a human layer 5 cortical pyramidal neuron. Model development balanced prioritizing current clamp data from the neuron providing the model’s morphology, while also ensuring the model’s generalizability via preservation of spiking properties observed in a secondary population of neurons, by “cycling” between these data sets. The model was successfully validated against electrophysiological data not used in model development, including experimentally observed subthreshold resonance characteristics. Our model highlights kinetic differences in the h-current across species, with the unique relationship between the model and experimental data allowing for a detailed investigation of the relationship between the h-current and subthreshold resonance.