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β-L-1-[5-(E-2-Bromovinyl)-2-(hydroxymethyl)-1,3-dioxolan-4-yl)] uracil (L-BHDU) effectiveness against varicella-zoster virus and herpes simplex virus type 1 depends on thymidine kinase activity
Chandrav De, Dongmei Liu, Daniel Depledge, Judith Breuer, Uma S. Singh, Caroll Hartline, Mark N. Prichard, Chung K. Chu, Jennifer F. Moffat
doi: https://doi.org/10.1101/2020.02.13.948190
Chandrav De
aDepartment of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, NC, USA
Dongmei Liu
bDepartment of Microbiology and Immunology, State University of New York Upstate Medical University, Syracuse NY, USA
Daniel Depledge
cMRC/UCL Centre for Medical Molecular Virology, Division of Infection & Immunity, University College London, UK
Judith Breuer
cMRC/UCL Centre for Medical Molecular Virology, Division of Infection & Immunity, University College London, UK
Uma S. Singh
eDepartment of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens GA, USA
Caroll Hartline
dDepartment of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA
Mark N. Prichard
dDepartment of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA
Chung K. Chu
eDepartment of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens GA, USA
Jennifer F. Moffat
bDepartment of Microbiology and Immunology, State University of New York Upstate Medical University, Syracuse NY, USA
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Posted February 14, 2020.
β-L-1-[5-(E-2-Bromovinyl)-2-(hydroxymethyl)-1,3-dioxolan-4-yl)] uracil (L-BHDU) effectiveness against varicella-zoster virus and herpes simplex virus type 1 depends on thymidine kinase activity
Chandrav De, Dongmei Liu, Daniel Depledge, Judith Breuer, Uma S. Singh, Caroll Hartline, Mark N. Prichard, Chung K. Chu, Jennifer F. Moffat
bioRxiv 2020.02.13.948190; doi: https://doi.org/10.1101/2020.02.13.948190
β-L-1-[5-(E-2-Bromovinyl)-2-(hydroxymethyl)-1,3-dioxolan-4-yl)] uracil (L-BHDU) effectiveness against varicella-zoster virus and herpes simplex virus type 1 depends on thymidine kinase activity
Chandrav De, Dongmei Liu, Daniel Depledge, Judith Breuer, Uma S. Singh, Caroll Hartline, Mark N. Prichard, Chung K. Chu, Jennifer F. Moffat
bioRxiv 2020.02.13.948190; doi: https://doi.org/10.1101/2020.02.13.948190
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