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Rapid quantitative imaging of high intensity ultrasonic pressure fields

Huiwen Luo, Jiro Kusunose, Gianmarco Pinton, Charles F Caskey, View ORCID ProfileWilliam A Grissom
doi: https://doi.org/10.1101/2020.02.15.951046
Huiwen Luo
1Vanderbilt University Institute of Imaging Science, Nashville, TN, USA
2Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA
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Jiro Kusunose
1Vanderbilt University Institute of Imaging Science, Nashville, TN, USA
3Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, USA
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Gianmarco Pinton
4Department of Biomedical Engineering, University of North Carolina, Chapel Hill, NC, USA
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Charles F Caskey
1Vanderbilt University Institute of Imaging Science, Nashville, TN, USA
2Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA
3Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, USA
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William A Grissom
1Vanderbilt University Institute of Imaging Science, Nashville, TN, USA
2Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA
3Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, USA
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  • ORCID record for William A Grissom
  • For correspondence: will.grissom@vanderbilt.edu
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Abstract

High-intensity focused ultrasound (FUS) is a noninvasive technique for thermal or mechanical treatment of tissues that can lie deep within the body, with a growing body of FDA-approved indications. There is a pressing need for methods to rapidly and quantitatively map FUS beams for quality assurance in the clinic, and to accelerate research and development of new FUS systems and techniques. However, conventional ultrasound pressure beam mapping instruments including hydrophones and optical techniques are slow, not portable, and expensive, and most cannot map beams at actual therapeutic pressure levels. Here, we report a rapid projection imaging method to quantitatively map FUS pressure beams based on continuous-wave background-oriented schlieren (CW-BOS) imaging. The method requires only a water tank, a background pattern and a camera, and uses a multi-layer deep neural network to reconstruct beam maps. Results at two FUS frequencies show that CW-BOS imaging can produce high-resolution quantitative projected FUS pressure maps in under ten seconds, that the technique is linear and robust to beam rotations and translations, and that it can accurately map aberrated beams.

Footnotes

  • https://github.com/wgrissom/zebrography

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted February 16, 2020.
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Rapid quantitative imaging of high intensity ultrasonic pressure fields
Huiwen Luo, Jiro Kusunose, Gianmarco Pinton, Charles F Caskey, William A Grissom
bioRxiv 2020.02.15.951046; doi: https://doi.org/10.1101/2020.02.15.951046
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Rapid quantitative imaging of high intensity ultrasonic pressure fields
Huiwen Luo, Jiro Kusunose, Gianmarco Pinton, Charles F Caskey, William A Grissom
bioRxiv 2020.02.15.951046; doi: https://doi.org/10.1101/2020.02.15.951046

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